Cytoreduction Results in High Perioperative Mortality and Decreased Survival in Patients Undergoing Pancreatectomy for Neuroendocrine Tumors of the Pancreas

We reviewed our experience with pancreatectomy for neuroendocrine tumors (NE) to determine outcomes after R0/R1 or R2 resection and compare them to patients in whom resection was not attempted. Data were reviewed for all patients presenting with NE tumors of the pancreas between 1990 and 2005. Kapla...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2006-12, Vol.10 (10), p.1361-1370
Main Authors: Bloomston, Mark, Muscarella, Peter, Shah, Manisha H., Frankel, Wendy L., Al-Saif, Osama, Martin, Edward W., Ellison, E. Christopher
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Islet Cell - mortality
Carcinoma, Islet Cell - surgery
endocrine
Female
Humans
islet cell carcinoma
Male
Medical research
Middle Aged
Mortality
Multivariate Analysis
Neuroendocrine
Neuroendocrine Tumors - mortality
Neuroendocrine Tumors - surgery
pancreas
Pancreatectomy
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - surgery
Proportional Hazards Models
survival
Survival Analysis
Survival Rate
Treatment Outcome
Tumors
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Summary:We reviewed our experience with pancreatectomy for neuroendocrine tumors (NE) to determine outcomes after R0/R1 or R2 resection and compare them to patients in whom resection was not attempted. Data were reviewed for all patients presenting with NE tumors of the pancreas between 1990 and 2005. Kaplan-Meier survival curves were compared by log-rank analysis. Multivariate analysis was completed using Cox proportional hazards to identify risk factors for poor survival after resection. Of 120 patients, 65 (54%) had functional tumors. Resection was undertaken in 83: distal pancreatectomy in 41, pancreaticoduodenectomy in 27, enucleation in 14, and central pancreatectomy in 1. Survival was significantly longer after resection (91 months versus 24, P < 0.001). R0/R1 resection was accomplished in 64 (77%) and resulted in lower perioperative mortality (2% versus 21%, P < 0.01) and longer survival (112 months versus 24, P < 0.001) compared to R2 resection. Survival after R2 resection was no better than after no resection. Factors predictive of decreased survival were moderate/poor differentiation, R2 resection, and high-risk features. Long-term survival is possible following complete resection for NE tumors of the pancreas. However, cytoreduction resulting in incomplete tumor removal carries significant perioperative mortality without long-term survival benefit and should be discouraged.
ISSN:1091-255X
1873-4626
DOI:10.1016/j.gassur.2006.09.004