Vascular endothelial dysfunction is associated with reversible myocardial perfusion defects in the absence of obstructive coronary artery disease

The purpose of this study was to investigate whether endothelial dysfunction contributes to abnormal myocardial perfusion imaging (MPI) observed in patients without obstructive coronary artery disease (CAD). It is unclear whether reversible MPI defects detected in the absence of obstructive CAD repr...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2006-11, Vol.13 (6), p.756-760
Main Authors: Soman, Prem, Dave, Devang M., Udelson, James E., Han, Hui, Ouda, Husam Z., Patel, Ayan R., Karas, Richard H., Kuvin, Jeffrey T.
Format: Article
Language:English
Subjects:
brachial artery
Cardiovascular disease
coronary artery disease
Coronary Disease - complications
Coronary Disease - diagnostic imaging
Coronary Stenosis - diagnostic imaging
Endothelial function
Endothelium, Vascular - diagnostic imaging
Exercise Test
Female
Humans
Male
Medical imaging
Middle Aged
Multivariate analysis
myocardial perfusion
Reproducibility of Results
Risk Assessment - methods
Risk Factors
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon - methods
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - etiology
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Summary:The purpose of this study was to investigate whether endothelial dysfunction contributes to abnormal myocardial perfusion imaging (MPI) observed in patients without obstructive coronary artery disease (CAD). It is unclear whether reversible MPI defects detected in the absence of obstructive CAD represent underlying vascular pathology or are false-positive MPI results. Recent evidence suggests that coronary endothelial dysfunction might play a role in the pathogenesis of these defects. We prospectively recruited 36 patients with chest discomfort, reversible abnormalities on MPI, and nonobstructive or absent CAD (stenosis
ISSN:1071-3581
1532-6551
DOI:10.1016/j.nuclcard.2006.08.018