Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181

B-cell chronic lymphocytic leukemia (B-CLL) is the most common human leukemia in the world. Deregulation of the TCL1 oncogene is a causal event in the pathogenesis of the aggressive form of this disease as was verified by using animal models. To study the mechanism of Tcl1 regulation in CLL, we carr...

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Published in:Cancer research (Chicago, Ill.) Ill.), 2006-12, Vol.66 (24), p.11590-11593
Main Authors: PEKARSKY, Yuri, SANTANAM, Urmila, CALIN, George A, HAGAN, John P, KIPPS, Thomas, CROCE, Carlo M, CIMMINO, Amelia, PALAMARCHUK, Alexey, EFANOV, Alexey, MAXIMOV, Vadim, VOLINIA, Stefano, ALDER, Hansjuerg, LIU, Chang-Gong, RASSENTI, Laura
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Chromosome Deletion
Chromosomes, Human, Pair 11
Gene Expression Regulation, Neoplastic
Hematologic and hematopoietic diseases
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
MicroRNAs - genetics
Oligonucleotide Array Sequence Analysis
Pharmacology. Drug treatments
Proto-Oncogene Proteins - genetics
Tumors
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Summary:B-cell chronic lymphocytic leukemia (B-CLL) is the most common human leukemia in the world. Deregulation of the TCL1 oncogene is a causal event in the pathogenesis of the aggressive form of this disease as was verified by using animal models. To study the mechanism of Tcl1 regulation in CLL, we carried out microRNA expression profiling of three types of CLL: indolent CLL, aggressive CLL, and aggressive CLL showing 11q deletion. We identified distinct microRNA signatures corresponding to each group of CLL. We further determined that Tcl1 expression is regulated by miR-29 and miR-181, two microRNAs differentially expressed in CLL. Expression levels of miR-29 and miR-181 generally inversely correlated with Tcl1 expression in the CLL samples we examined. Our results suggest that Tcl1 expression in CLL is, at least in part, regulated by miR-29 and miR-181 and that these microRNAs may be candidates for therapeutic agents in CLLs overexpressing Tcl1.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-06-3613