An expanded version of the Hammersmith Functional Motor Scale for SMA II and III patients

Abstract Purpose To develop and evaluate an expanded version of the Hammersmith Functional Motor Scale allowing for evaluation of ambulatory SMA patients. Procedures Thirty-eight patients with SMA type II or III were evaluated using the Gross Motor Function Measure and the Hammersmith Functional Mot...

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Bibliographic Details
Published in:Neuromuscular disorders : NMD 2007-10, Vol.17 (9), p.693-697
Main Authors: O’Hagen, Jessica M, Glanzman, Allan M, McDermott, Michael P, Ryan, Patricia A, Flickinger, Jean, Quigley, Janet, Riley, Susan, Sanborn, Erica, Irvine, Carrie, Martens, William B, Annis, Christine, Tawil, Rabi, Oskoui, Maryam, Darras, Basil T, Finkel, Richard S, De Vivo, Darryl C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
Disability Evaluation
Female
Gross Motor Function Measure
Hammersmith Functional Motor Scale
Humans
Male
Motor Activity - physiology
Neurology
Outcome measure
Physical therapy
Reproducibility of Results
Severity of Illness Index
Spinal Muscular Atrophies of Childhood - diagnosis
Spinal Muscular Atrophies of Childhood - physiopathology
Spinal Muscular Atrophy
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Summary:Abstract Purpose To develop and evaluate an expanded version of the Hammersmith Functional Motor Scale allowing for evaluation of ambulatory SMA patients. Procedures Thirty-eight patients with SMA type II or III were evaluated using the Gross Motor Function Measure and the Hammersmith Functional Motor Scale. Based on statistical and clinical criteria, we selected 13 Gross Motor Function Measure items to develop an expanded HFMS. The expanded Hammersmith Functional Motor Scale was validated by comparison with the Gross Motor Function Measure minus the 13 items (GMFM-75) and an assessment of clinical function. The reliability of the expanded Hammersmith Functional Motor Scale in 36 patients was established. Findings The expanded Hammersmith Functional Motor Scale was highly correlated with the GMFM-75 and the clinical function assessment ( p = 0.97, and p = 0.90). The expanded Hammersmith Functional Motor Scale showed excellent test–retest reliability (International Coordinating Committee = 0.99). Conclusions The expanded Hammersmith Functional Motor Scale allows assessment of high functioning SMA type II and III patients. Ease of administration and correlation with established motor function measures justify use in future SMA clinical trials.
ISSN:0960-8966
1873-2364
DOI:10.1016/j.nmd.2007.05.009