Synthesis of Novel 1-Pyrazolylpyridin-2-ones as Potential Anti-Inflammatory and Analgesic Agents

A new series of 4‐alkyl/aryl‐2‐oxo‐1‐pyrazolyl‐1,2‐dihydropyridine‐3‐carbonitriles, pyrazolo[3,4‐b]pyridine‐5‐carbonitriles and pyrido[2,3‐d]pyrimidine‐6‐carbonitriles have been synthesized and tested for their anti‐inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibit...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 2007-09, Vol.340 (9), p.476-482
Main Authors: Ismail, Magda M. F., Ammar, Yousry A., El-Zahaby, Heba S. A., Eisa, Sally I., El-Sayed Barakat, Saber
Format: Article
Language:English
Subjects:
1-Pyrazolylpyridin-2-one
Analgesic activities
Animals
Anti-inflammatory
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Condensed pyridone
Female
Male
Pain - drug therapy
Pyridones - chemical synthesis
Pyridones - chemistry
Pyridones - pharmacology
Rats
Structure-Activity Relationship
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Summary:A new series of 4‐alkyl/aryl‐2‐oxo‐1‐pyrazolyl‐1,2‐dihydropyridine‐3‐carbonitriles, pyrazolo[3,4‐b]pyridine‐5‐carbonitriles and pyrido[2,3‐d]pyrimidine‐6‐carbonitriles have been synthesized and tested for their anti‐inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti‐inflammatory activity to the standard (indomethacin). Compounds 5, 7a, and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.200600197