Synthesis of Novel 1-Pyrazolylpyridin-2-ones as Potential Anti-Inflammatory and Analgesic Agents

A new series of 4‐alkyl/aryl‐2‐oxo‐1‐pyrazolyl‐1,2‐dihydropyridine‐3‐carbonitriles, pyrazolo[3,4‐b]pyridine‐5‐carbonitriles and pyrido[2,3‐d]pyrimidine‐6‐carbonitriles have been synthesized and tested for their anti‐inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibit...

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Published in:Archiv der Pharmazie (Weinheim) 2007-09, Vol.340 (9), p.476-482
Main Authors: Ismail, Magda M. F., Ammar, Yousry A., El-Zahaby, Heba S. A., Eisa, Sally I., El-Sayed Barakat, Saber
Format: Article
Language:English
Subjects:
1-Pyrazolylpyridin-2-one
Analgesic activities
Animals
Anti-inflammatory
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Condensed pyridone
Female
Male
Pain - drug therapy
Pyridones - chemical synthesis
Pyridones - chemistry
Pyridones - pharmacology
Rats
Structure-Activity Relationship
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cited_by cdi_FETCH-LOGICAL-c4127-9b009e30ce6576d66e6678b49d64e301018525cca7f15d1ed38a20086bb872f43
cites cdi_FETCH-LOGICAL-c4127-9b009e30ce6576d66e6678b49d64e301018525cca7f15d1ed38a20086bb872f43
container_end_page 482
container_issue 9
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container_title Archiv der Pharmazie (Weinheim)
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creator Ismail, Magda M. F.
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description A new series of 4‐alkyl/aryl‐2‐oxo‐1‐pyrazolyl‐1,2‐dihydropyridine‐3‐carbonitriles, pyrazolo[3,4‐b]pyridine‐5‐carbonitriles and pyrido[2,3‐d]pyrimidine‐6‐carbonitriles have been synthesized and tested for their anti‐inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti‐inflammatory activity to the standard (indomethacin). Compounds 5, 7a, and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported.
doi_str_mv 10.1002/ardp.200600197
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subjects 1-Pyrazolylpyridin-2-one
Analgesic activities
Animals
Anti-inflammatory
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Condensed pyridone
Female
Male
Pain - drug therapy
Pyridones - chemical synthesis
Pyridones - chemistry
Pyridones - pharmacology
Rats
Structure-Activity Relationship
title Synthesis of Novel 1-Pyrazolylpyridin-2-ones as Potential Anti-Inflammatory and Analgesic Agents
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