Relevance of ineffective esophageal motility and hyperactive acid sensitization in patients with gastroesophageal reflux

Background and Aim:  Esophageal motor abnormalities including ineffective esophageal motility (IEM) and visceral hypersensitivity have been frequently observed in patients with gastroesophageal reflux. The aim of this study was to observe the incidences of hypersensitivity to acid infusion and motor...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2007-10, Vol.22 (10), p.1662-1665
Main Authors: Hong, Su Jin, Ko, Bong Min, Jung, In Seop, Ryu, Chang Beom, Moon, Jong Ho, Cho, Joo Young, Kim, Jin Oh, Lee, Joon Seong, Lee, Moon Sung, Shim, Chan Sup, Kim, Boo Sung
Format: Article
Language:English
Subjects:
acid sensitization
Adolescent
Adult
Aged
Biological and medical sciences
Chi-Square Distribution
Endoscopy, Gastrointestinal
Esophageal Motility Disorders - epidemiology
Esophageal Motility Disorders - etiology
Esophageal Motility Disorders - physiopathology
Esophageal pH Monitoring
Esophagitis, Peptic - epidemiology
Esophagitis, Peptic - etiology
Esophagitis, Peptic - physiopathology
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - complications
Gastroesophageal Reflux - epidemiology
Gastroesophageal Reflux - physiopathology
Humans
ineffective esophageal motility
Korea - epidemiology
Male
Manometry
Medical sciences
Middle Aged
Other diseases. Semiology
Prospective Studies
reflux symptoms
Risk Factors
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Summary:Background and Aim:  Esophageal motor abnormalities including ineffective esophageal motility (IEM) and visceral hypersensitivity have been frequently observed in patients with gastroesophageal reflux. The aim of this study was to observe the incidences of hypersensitivity to acid infusion and motor abnormalities in non‐erosive reflux disease (NERD) compared with erosive esophagitis. Methods:  We performed upper GI endoscopy, an acid perfusion test and esophageal manometry on 113 NERD patients and 37 erosive esophagitis patients. Results:  The frequency of acid sensitization was 69.9% in NERD and 67.6% in erosive esophagitis. The frequency of esophageal motor abnormality in patients with erosive esophagitis (48.6%) was higher than in patients with NERD (25.7%, P = 0.014). The most frequent esophageal motor abnormality was IEM. The frequency of IEM was 15.9% in NERD patients, 42.9% in Los Angeles grade A, 53.8% in Los Angeles grade B and 66.7% in Los Angeles grade C esophagitis (χ2 = 16.67, P 
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2007.04987.x