Deltaran prevents an adverse effect of emotional stress on the course of cerebral ischemia in low-resistant animals

Local cerebral blood flow in the left hemisphere decreased most significantly in low-resistant Wistar rats preexposed to emotional stress. Deltaran selectively increased blood flow in the left hemisphere and improved blood supply to neuronal activity unit of the brain in these animals. This drug pre...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-05, Vol.141 (5), p.564-566
Main Authors: Konorova, I L, Gannushkina, I V, Koplik, E V, Antelava, A L
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - mortality
Brain Ischemia - pathology
Delta Sleep-Inducing Peptide - pharmacology
Delta Sleep-Inducing Peptide - therapeutic use
Drug Combinations
Electroencephalography
Glycine - pharmacology
Glycine - therapeutic use
Male
Rats
Rats, Wistar
Regional Blood Flow - drug effects
Stress, Psychological - drug therapy
Stress, Psychological - physiopathology
Telencephalon - blood supply
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Summary:Local cerebral blood flow in the left hemisphere decreased most significantly in low-resistant Wistar rats preexposed to emotional stress. Deltaran selectively increased blood flow in the left hemisphere and improved blood supply to neuronal activity unit of the brain in these animals. This drug prevented progressive decrease in local cerebral blood flow in both hemispheres during the acute stage of ischemia. The effect of Deltaran was related to modulation of collateral blood flow and adequate blood supply to neuronal activity unit in the brain tissue. Deltaran decreased the mortality rate (by 62%) and alleviated the symptoms of cerebral ischemia. The positive effect of Deltaran was more pronounced in the left hemisphere.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0221-1