Histological and ultrastructural features of gastrointestinal basidiobolomycosis

Basidiobolus ranarum is a fungus found in the dung of amphibians, reptiles, and insectivorous bats. Its structural elements include both hyphae and zygospores. Patients with B. ranarum infection may present with subcutaneous, gastrointestinal, or systemic lesions. Here we report a case of gastrointe...

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Bibliographic Details
Published in:Mycological research 2007-08, Vol.111 (8), p.926-930
Main Authors: Hussein, Mahmoud R., Musalam, Adel O., Assiry, Mubarak H., Eid, Refaat A., El Motawa, Abdel-Moneam, Gamel, Abdel-Moneam
Format: Article
Language:English
Subjects:
acute course
Adolescent
animal pathogenic fungi
Basidiobolomycosis
Basidiobolus
Basidiobolus ranarum
case studies
Colon - pathology
Colon - ultrastructure
digestive system diseases
Entomophthorales - isolation & purification
Entomophthorales - pathogenicity
Gastrointestinal Diseases - microbiology
Gastrointestinal Diseases - pathology
histopathology
Humans
Infection
Intestine
Male
mycoses
Zygomycosis - microbiology
Zygomycosis - pathology
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Summary:Basidiobolus ranarum is a fungus found in the dung of amphibians, reptiles, and insectivorous bats. Its structural elements include both hyphae and zygospores. Patients with B. ranarum infection may present with subcutaneous, gastrointestinal, or systemic lesions. Here we report a case of gastrointesinal badidiomycosis in a 13-year-old male child who presented with acute abdomen. Exploration revealed a mass in the ascending colon. On histology, transmural granulomatous inflammation composed of abundant eosinophils, lymphocytes, histiocytes and giant cells was seen. Histochemical stains revealed broad, non-septate, hyphae-like structures surrounded by an eosinophilic sheath. On an ultrastructural level, fungal hyphae, spores, and macrophage-laden crystalloids were observed. The diagnosis of gastrointestinal basidiobolomycosis was established and the patient received antifungal treatment. This paper reviews the relevant literature regarding basidiomycosis, and discusses its diverse clinicopathological features, as well as distinguishing it from other diseases.
ISSN:0953-7562
1469-8102
DOI:10.1016/j.mycres.2007.06.009