Protein thermostability in Archaea and Eubacteria

In order to survive at high temperatures, thermophilic prokaryotes (Archaea and Eubacteria) adopt different strategies. Among several important contributing factors for stability of proteins are CG-rich codons, the ratio of charged amino acids compared to uncharged amino acids, ionic interactions, a...

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Bibliographic Details
Published in:Genetics and molecular research 2006-01, Vol.5 (4), p.816-827
Main Authors: Trivedi, S, Gehlot, H S, Rao, S R
Format: Article
Language:English
Subjects:
Adaptation, Biological
Amino Acids - metabolism
Archaea
Archaea - genetics
Archaea - metabolism
Archaeal Proteins - metabolism
Bacteria - genetics
Bacteria - metabolism
Bacterial Proteins - metabolism
Eubacteria
Hot Temperature
Structure-Activity Relationship
Thermodynamics
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Summary:In order to survive at high temperatures, thermophilic prokaryotes (Archaea and Eubacteria) adopt different strategies. Among several important contributing factors for stability of proteins are CG-rich codons, the ratio of charged amino acids compared to uncharged amino acids, ionic interactions, amino acid preferences and their distribution, post-translational modifications, and solute accumulation. However, these factors may differ from taxon to taxon, both within and between species depending upon the composition of proteins found in these organisms. This is exemplified in the case of differences in strategies adopted by soluble proteins and membrane proteins. Therefore, it appears that no single factor or combination of factors together can be universally attributed to the provision of thermal stability in proteins.
ISSN:1676-5680
1676-5680