Hypoxia at the Site of Abdominal Aortic Aneurysm Rupture Is Not Associated with Increased Lactate

:  The mechanisms of hypoxia‐mediated aneurysm wall weakening and rupture are unknown. During hypoxia, strategies to maintain cellular ATP levels include increasing glycolysis (glycolytic strategy) or decreasing ATP consumption (metabolic depression). This study demonstrated that compared to anterio...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2006-11, Vol.1085 (1), p.306-310
Main Authors: CHOKE, EDWARD, COCKERILL, GILLIAN W., DAWSON, JOSEPH, CHUNG, YUEN-LI, GRIFFITHS, JOHN, WILSON, RICHARD W., LOFTUS, IAN M., THOMPSON, MATTHEW M.
Format: Article
Language:English
Subjects:
abdominal aortic aneurysm
Aortic Aneurysm, Abdominal - metabolism
Aortic Rupture - metabolism
Biomarkers
glycolysis
Humans
hypoxia
Hypoxia - metabolism
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
lactate
Lactates - metabolism
protein synthesis
rupture
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Summary::  The mechanisms of hypoxia‐mediated aneurysm wall weakening and rupture are unknown. During hypoxia, strategies to maintain cellular ATP levels include increasing glycolysis (glycolytic strategy) or decreasing ATP consumption (metabolic depression). This study demonstrated that compared to anterior aneurysm sac, rupture edge overexpressed hypoxia‐inducible factor‐1‐α (marker of hypoxia) and showed no significant difference in levels of combined ADP and ATP or lactate (glycolytic end product). Further studies are needed to confirm whether hypoxic AAA cells adapt through metabolic depression rather than glycolysis. The downregulation of protein synthesis during such metabolic depression may be a factor in hypoxia‐mediated wall weakening.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1383.005