Convergence of Quantum Dot Barcodes with Microfluidics and Signal Processing for Multiplexed High-Throughput Infectious Disease Diagnostics

Through the convergence of nano- and microtechnologies (quantum dots and microfluidics), we have created a diagnostic system capable of multiplexed, high-throughput analysis of infectious agents in human serum samples. We demonstrate, as a proof-of-concept, the ability to detect serum biomarkers of...

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Bibliographic Details
Published in:Nano letters 2007-09, Vol.7 (9), p.2812-2818
Main Authors: Klostranec, Jesse M, Xiang, Qing, Farcas, Gabriella A, Lee, Jeongjin A, Rhee, Alex, Lafferty, Erin I, Perrault, Steven D, Kain, Kevin C, Chan, Warren C. W
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Biomarkers - blood
Biotechnology
Blood Chemical Analysis - instrumentation
Blood Chemical Analysis - methods
Cross-disciplinary physics: materials science
rheology
Diagnosis, Computer-Assisted - instrumentation
Electronics
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Human immunodeficiency virus
Humans
Materials science
Methods. Procedures. Technologies
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
Molecular electronics, nanoelectronics
Nanocrystalline materials
Nanoscale materials and structures: fabrication and characterization
Others
Physics
Quantum Dots
Semiconductor electronics. Microelectronics. Optoelectronics. Solid state devices
Signal Processing, Computer-Assisted - instrumentation
Spectrometry, Fluorescence - instrumentation
Spectrometry, Fluorescence - methods
Systems Integration
Various methods and equipments
Virus Diseases - blood
Virus Diseases - diagnosis
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Summary:Through the convergence of nano- and microtechnologies (quantum dots and microfluidics), we have created a diagnostic system capable of multiplexed, high-throughput analysis of infectious agents in human serum samples. We demonstrate, as a proof-of-concept, the ability to detect serum biomarkers of the most globally prevalent blood-borne infectious diseases (i.e., hepatitis B, hepatitis C, and HIV) with low sample volume (
ISSN:1530-6984
1530-6992
DOI:10.1021/nl071415m