Inhibitory Effects of Peony Root Extract on the Large Conductance Calcium-Activated Potassium Current Essential in Production of Bursting Activity

To elucidate the mechanism of inhibitory action of peony root extract on pentylenetetrazol-induced bursting activity, effects of peony root extract on the iberiotoxin-sensitive large conductance calcium-activated potassium (BKCa) current that plays an essential role in the production of bursting act...

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Bibliographic Details
Published in:Journal of herbal pharmacotherapy 2006, Vol.6 (2), p.65-77
Main Authors: Sugaya, Eiichi, Jin, Wen, Sugaya, Aiko, Sunaga, Katsuyoshi, Tsuda, Tadashi
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Animals
anti-convulsant drugs
Anticonvulsants - administration & dosage
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
bursting activity
Cells, Cultured
Cerebral Cortex - cytology
Cerebral Cortex - embryology
channel current
EL mouse
epilepsy
Mice
Mice, Inbred Strains
Paeonia
Peony root extract
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Potassium Channels, Calcium-Activated - drug effects
Seizures - drug therapy
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Summary:To elucidate the mechanism of inhibitory action of peony root extract on pentylenetetrazol-induced bursting activity, effects of peony root extract on the iberiotoxin-sensitive large conductance calcium-activated potassium (BKCa) current that plays an essential role in the production of bursting activity were investigated. Peony root extract showed a clear inhibitory effect on the iberiotoxin-sensitive calcium-activated potassium current. Peony root extract also showed clear inhibitory effects on spontaneous bursting activity and BKCa current in the cerebral cortical neurons of the EL mouse, a hereditary epilepsy animal model. These results together with our previous studies, including the protective effect against neuron damage, indicate that peony root extract is a promising herbal drug for inhibition of convulsions.
ISSN:1522-8940
1522-9106
DOI:10.1080/J157v06n02_06