Serum resistin increases in a postprandial state during liquid meal challenge test in healthy human subjects

The role of resistin in humans is controversial although resistin has been linked to atherosclerotic and inflammatory processes. In rodents, resistin expression is suppressed after food restriction while central administration of resistin promotes short-term satiety. However, the nature of postprand...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2006-11, Vol.29 (10), p.RC27-RC30
Main Authors: Gruendel, S, Weickert, M O, Garcia, A L, Wagner, K, Pfeiffer, A F H, Harsch, I, Koebnick, C
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - metabolism
Case-Control Studies
Fatty Acids, Nonesterified - blood
Female
Food, Formulated
Humans
Insulin - blood
Male
Middle Aged
Pilot Projects
Postprandial Period
Resistin - blood
Triglycerides - blood
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Summary:The role of resistin in humans is controversial although resistin has been linked to atherosclerotic and inflammatory processes. In rodents, resistin expression is suppressed after food restriction while central administration of resistin promotes short-term satiety. However, the nature of postprandial responses in circulating resistin in humans is unknown. Therefore, we investigated postprandial resistin concentrations in a pilot study in 19 healthy subjects and 19 controls matched for age and body mass index (BMI). Serum resistin, insulin and non-esterified fatty acids (NEFA) concentrations as well as plasma glucose and triglycerides were repeatedly assessed before and after ingestion of an isocaloric standardized liquid meal during a 300 min period.After consumption of liquid meal, serum resistin levels increased compared to fasting control (p=0.037). Postprandial plasma glucose and serum insulin increased (p
ISSN:0391-4097
1720-8386
DOI:10.1007/bf03349186