Cleavage Agents for Soluble Oligomers of Amyloid β Peptides

Clearing the mind: Peptide‐cleaving agents for amyloid β‐42 (Aβ42) oligomers (see scheme), the intermediate neurotoxic species in the pathology of Alzheimer's disease, have been obtained from a combinatorial library built using the CoIII complex of 1,4,7,10‐tetraazacyclododecane as the reaction...

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Published in:Angewandte Chemie (International ed.) 2007-01, Vol.46 (37), p.7064-7067
Main Authors: Suh, Junghun, Yoo, Sang Ho, Kim, Min Gyum, Jeong, Keunhong, Ahn, Jae Young, Kim, Myoung-soon, Chae, Pil Seok, Lee, Tae Yeon, Lee, Jaehwa, Lee, Jeongkuk, Jang, Yun Ah, Ko, Eun Hwa
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - metabolism
amyloid β peptides
combinatorial chemistry
drug design
Humans
Molecular Structure
peptide cleavage
Peptide Fragments - chemistry
Peptide Fragments - metabolism
Protein Structure, Quaternary
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Summary:Clearing the mind: Peptide‐cleaving agents for amyloid β‐42 (Aβ42) oligomers (see scheme), the intermediate neurotoxic species in the pathology of Alzheimer's disease, have been obtained from a combinatorial library built using the CoIII complex of 1,4,7,10‐tetraazacyclododecane as the reaction center. Effective cleavage of the Aβ42 oligomers occurs at submicromolar concentrations of the agents.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200702399