Striatal dopaminergic neurons are lost with Parkinson's disease progression

Increased numbers of dopaminergic neurons are described in the striatum of patients with Parkinson's disease. In postmortem striatal tissue from Parkinson's disease patients with short disease duration (≤8 years), the number of dopaminergic neurons is approximately four times that in patie...

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Bibliographic Details
Published in:Movement disorders 2006-12, Vol.21 (12), p.2208-2211
Main Authors: Porritt, Michelle J., Kingsbury, Ann E., Hughes, Andrew J., Howells, David W.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Cell Death - physiology
Corpus Striatum - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Progression
Dopamine - metabolism
dopaminergic neuron
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Immunohistochemistry
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neurons - metabolism
Parkinson Disease - pathology
Parkinson's disease
striatum
Time Factors
Tyrosine 3-Monooxygenase - metabolism
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Summary:Increased numbers of dopaminergic neurons are described in the striatum of patients with Parkinson's disease. In postmortem striatal tissue from Parkinson's disease patients with short disease duration (≤8 years), the number of dopaminergic neurons is approximately four times that in patients with long duration (≥16 years). The data suggest the possibility that the presence of large numbers of these striatal dopaminergic neurons may be harmful and may accelerate the disease process. Alternatively, these neurons may be lost to the disease process. © 2006 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.21129