Altered glycosylation of acetylcholinesterase in the Creutzfeldt-Jakob cerebrospinal fluid

Several neurodegenerative disorders present deficiencies in the cholinergic system. Scarce research on prion encephalopathies has examined the levels of cholinergic pathway-related enzymes. Acetylcholinesterase (AChE) is expressed as several molecular forms. The potential importance of these variant...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2006-01, Vol.30 (1-2), p.65-66
Main Authors: Silveyra, Maria-Ximena, García-Ayllón, Maria-Salud, Calero, Miguel, Sáez-Valero, Javier
Format: Article
Language:English
Subjects:
Acetylcholinesterase - cerebrospinal fluid
Creutzfeldt-Jakob Syndrome - cerebrospinal fluid
Creutzfeldt-Jakob Syndrome - enzymology
Glycosylation
Humans
Reference Values
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Summary:Several neurodegenerative disorders present deficiencies in the cholinergic system. Scarce research on prion encephalopathies has examined the levels of cholinergic pathway-related enzymes. Acetylcholinesterase (AChE) is expressed as several molecular forms. The potential importance of these variants is increased by the possibility that AChE has roles other than acetylcholine hydrolysis. We investigated the levels of AChE, its molecular forms, and glycosylation in the cerebrospinal fluid (CSF) from Creutzfeldt-Jakob disease (CJD) patients.
ISSN:0895-8696
0895-8696
1559-1166
DOI:10.1385/JMN:30:1:65