Effects of selenium and tellurium on the activity of selenoenzymes glutathione peroxidase and type I iodothyronine deiodinase, trace element thyroid level, and thyroid hormone status in rats

• Published in: Biological trace element research 2007-06, Vol.117 (1-3), p.105-114
• Main Authors: Eybl, Vladislav, Kotyzová, Dana, Sýkora, Jindrich, Topolcan, Ondrej, Pikner, Richard, Mihaljevic, Martin, Brtko, Július, Glattre, Eystein
• Format: Article
• Language: English
• Subjects: Animals; Body weight; Body Weight - physiology; Chemical interactions; Drinking water; Female; Glutathione Peroxidase - metabolism; Iodide Peroxidase - metabolism; Iodine; Organ Size - physiology; Rats; Rats, Wistar; Rodents; Selenium; Selenium - physiology; Sodium; Tellurium; Tellurium - physiology; Thyroid; Thyroid gland; Thyroid Gland - anatomy & histology; Thyroid Gland - metabolism; Thyroid Hormones - metabolism; Trace elements; Trace Elements - metabolism
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/BF02698087

Tellurium (Te) and selenium (Se) belong chemically to the VIa group of elements. Se represents an essential element closely related to thyroid function. Te has growing application in industrial processes. Little is known about the Te biological activity, particularly with respect to potential chemical interactions with Se-containing components in the organism. In this study, female Wistar rats (body weight: 115-120 g) received sodium selenite pentahydrate (10 mg/L) or sodium tellurite (9.4 mg/L) in drinking water for 6 wk. Additional groups of rats received their combination with zinc sulfate heptahydrate (515 mg/L). The stimulation of 5'-DI-I activity due to selenite (to 158%, p