Growth-suppressive Function of Phosphatidylethanolamine-binding Protein in Anaplastic Thyroid Cancer

Background: A cDNA microarray analysis of anaplastic thyroid cancer cell lines (ACL) was recently performed and the down-regulation of phosphatidylethanolamine-binding protein (PBP) [RAF kinase inhibitor protein (RKIP)] in ACL compared to normal thyroid tissues was identified. Materials and Methods:...

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Bibliographic Details
Published in:Anticancer research 2006-11, Vol.26 (6B), p.4437-4442
Main Authors: AKAISHI, Junko, ONDA, Masamitsu, ASAKA, Shinichi, OKAMOTO, Junichi, MIYAMOTO, Shizuyo, NAGAHAMA, Mitsuji, ITO, Kouichi, KAWANAMI, Oichi, SHIMIZU, Kazuo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Line, Tumor
Down-Regulation
Endocrinopathies
Humans
Malignant tumors
Medical sciences
Phosphatidylethanolamine Binding Protein - physiology
Reverse Transcriptase Polymerase Chain Reaction
Thyroid Neoplasms - pathology
Thyroid. Thyroid axis (diseases)
Tumors
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Summary:Background: A cDNA microarray analysis of anaplastic thyroid cancer cell lines (ACL) was recently performed and the down-regulation of phosphatidylethanolamine-binding protein (PBP) [RAF kinase inhibitor protein (RKIP)] in ACL compared to normal thyroid tissues was identified. Materials and Methods: The expression levels of PBP in primary anaplastic and papillary thyroid cancer, thyroid cancer cell lines (anaplastic, papillary and follicular) and several normal human organs were examined. To examine the function of PBP, cell-growth assays were performed. Results: PBP expression was reduced in anaplastic thyroid cancers, compared to either normal thyroid tissues or differentiated thyroid cancers. PBP was expressed ubiquitously in normal human tissues. Exogenous PBP expression suppressed ACL growth, and suggested a tumor suppressive function of PBP in ACL. Conclusion: This is the first report demonstrating that PBP may be a tumor suppressor whose loss is associated with development of anaplastic thyroid cancer from differentiated thyroid cancer.
ISSN:0250-7005
1791-7530