Assessment of the optimal temporal window for intravenous CT cholangiography

The optimal temporal window of intravenous (IV) computed tomography (CT) cholangiography was prospectively determined. Fifteen volunteers (eight women, seven men; mean age, 38 years) underwent dynamic CT cholangiography. Two unenhanced images were acquired at the porta hepatis. Starting 5 min after...

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Bibliographic Details
Published in:European radiology 2007-10, Vol.17 (10), p.2531-2537, Article 2531
Main Authors: Schindera, Sebastian T, Nelson, Rendon C, Paulson, Erik K, DeLong, David M, Merkle, Elmar M
Format: Article
Language:English
Subjects:
Adult
Attenuation
Bile ducts
Biliary tract
Body weight
Branches
Cholangiography - methods
Computed tomography
Contrast agents
Contrast media
Contrast Media - administration & dosage
Female
Humans
Image acquisition
Image contrast
Infusions, Intravenous
Intravenous administration
Male
Medical imaging
Middle Aged
Parenchyma
Time Factors
Tomography, X-Ray Computed
Visualization
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Summary:The optimal temporal window of intravenous (IV) computed tomography (CT) cholangiography was prospectively determined. Fifteen volunteers (eight women, seven men; mean age, 38 years) underwent dynamic CT cholangiography. Two unenhanced images were acquired at the porta hepatis. Starting 5 min after initiation of IV contrast infusion (20 ml iodipamide meglumine 52%), 15 pairs of images at 5-min intervals were obtained. Attenuation of the extrahepatic bile duct (EBD) and the liver parenchyma was measured. Two readers graded visualization of the higher-order biliary branches. The first biliary opacification in the EBD occurred between 15 and 25 min (mean, 22.3 min +/- 3.2) after initiation of the contrast agent. Biliary attenuation plateaued between the 35- and the 75-min time points. Maximum hepatic parenchymal enhancement was 18.5 HU +/- 2.7. Twelve subjects demonstrated poor or non-visualization of higher-order biliary branches; three showed good or excellent visualization. Body weight and both biliary attenuation and visualization of the higher-order biliary branches correlated significantly (P
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-007-0709-8