Dizygotic twins with congenital malalignment of the great toenails: Reappraisal of the pathogenesis

Congenital malalignment of the great toenails (CMGTN) is a heritable disorder, in which the longitudinal axis of the nail plate is not parallel to the corresponding axis of the distal phalanx of the hallux, but laterally deviated. We describe a pair of 1½-month-old dizygotic twins with laterally dev...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2007-10, Vol.57 (4), p.711-715
Main Authors: Chaniotakis, Ioannis, MD, Bonitsis, Nicolaos, MD, Stergiopoulou, Christina, MD, Kiorpelidou, Despoina, MD, Bassukas, Ioannis D., MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dermatology
Diseases in Twins - congenital
Diseases in Twins - genetics
Female
Humans
Infant
Male
Medical sciences
Nails, Malformed - congenital
Nails, Malformed - genetics
Pedigree
Remission, Spontaneous
Twins, Dizygotic
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Description
Summary:Congenital malalignment of the great toenails (CMGTN) is a heritable disorder, in which the longitudinal axis of the nail plate is not parallel to the corresponding axis of the distal phalanx of the hallux, but laterally deviated. We describe a pair of 1½-month-old dizygotic twins with laterally deviated nail plates of the great toenails since birth. By the time the infants were 10 months of age, significant realignment was observed. Adult pedigree members also showed slight similar deviations of the nail plates. We suggest that desynchronization of growth between the nail and the adherent end-phalanx of the hallux may result in temporarily larger nail plates, which are gliding outwards, in order to fit into the underlying bony space. During postnatal life, spontaneous realignment is usually observed, probably as a result of a faster growing end-phalanx.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2007.05.033