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Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy
Immune homeostasis is a delicate balance between the immune defense against foreign pathogens and suppression of the immune system to maintain self-tolerance and prevent autoimmune disease. Maintenance of this balance involves several crucial networks of cytokines and various cell types. Among these...
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| Published in: | Clinical cancer research 2007-09, Vol.13 (18), p.5262-5270 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c371t-7e0f3ddf66b0831b9382df1cc88d574959acce96a1dec7ac4762bc4773065fbf3 |
| container_end_page | 5270 |
| container_issue | 18 |
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| container_title | Clinical cancer research |
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| creator | WRZESINSKI, Stephen H WAN, Yisong Y FLAVELL, Richard A |
| description | Immune homeostasis is a delicate balance between the immune defense against foreign pathogens and suppression of the immune
system to maintain self-tolerance and prevent autoimmune disease. Maintenance of this balance involves several crucial networks
of cytokines and various cell types. Among these regulators, transforming growth factor-β (TGF-β) is a potent cytokine with
diverse effects on hematopoietic cells. Its pivotal function within the immune system is to maintain tolerance via the regulation
of lymphocyte proliferation, differentiation, and survival. In addition, TGF-β controls the initiation and resolution of inflammatory
responses through the regulation of chemotaxis and activation of leukocytes in the periphery, including lymphocytes, natural
killer cells, dendritic cells, macrophages, mast cells, and granulocytes. Through its pleiotropic effects on these immune
cells, TGF-β prevents the development of autoimmune diseases without compromising immune responses to pathogens. However,
overactivation of this pathway can lead to several immunopathologies under physiologic conditions including cancer progression,
making it an attractive target for antitumor therapies. This review discusses the biological functions of TGF-β and its effects
on the immune system and addresses how immunosuppression by this cytokine can promote tumorigenesis, providing the rationale
for evaluating the immune-enhancing and antitumor effects of inhibiting TGF-β in cancer patients. |
| doi_str_mv | 10.1158/1078-0432.CCR-07-1157 |
| format | article |
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system to maintain self-tolerance and prevent autoimmune disease. Maintenance of this balance involves several crucial networks
of cytokines and various cell types. Among these regulators, transforming growth factor-β (TGF-β) is a potent cytokine with
diverse effects on hematopoietic cells. Its pivotal function within the immune system is to maintain tolerance via the regulation
of lymphocyte proliferation, differentiation, and survival. In addition, TGF-β controls the initiation and resolution of inflammatory
responses through the regulation of chemotaxis and activation of leukocytes in the periphery, including lymphocytes, natural
killer cells, dendritic cells, macrophages, mast cells, and granulocytes. Through its pleiotropic effects on these immune
cells, TGF-β prevents the development of autoimmune diseases without compromising immune responses to pathogens. However,
overactivation of this pathway can lead to several immunopathologies under physiologic conditions including cancer progression,
making it an attractive target for antitumor therapies. This review discusses the biological functions of TGF-β and its effects
on the immune system and addresses how immunosuppression by this cytokine can promote tumorigenesis, providing the rationale
for evaluating the immune-enhancing and antitumor effects of inhibiting TGF-β in cancer patients.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-07-1157</identifier><identifier>PMID: 17875754</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Dendritic Cells - immunology ; Humans ; Immune Response ; Killer Cells, Natural - immunology ; Medical sciences ; Neoplasms - drug therapy ; Neoplasms - immunology ; Pharmacology. Drug treatments ; T-Lymphocytes - immunology ; TGF-β ; Transforming Growth Factor beta - antagonists & inhibitors ; Transforming Growth Factor beta - physiology</subject><ispartof>Clinical cancer research, 2007-09, Vol.13 (18), p.5262-5270</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-7e0f3ddf66b0831b9382df1cc88d574959acce96a1dec7ac4762bc4773065fbf3</citedby><cites>FETCH-LOGICAL-c371t-7e0f3ddf66b0831b9382df1cc88d574959acce96a1dec7ac4762bc4773065fbf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19164025$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17875754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WRZESINSKI, Stephen H</creatorcontrib><creatorcontrib>WAN, Yisong Y</creatorcontrib><creatorcontrib>FLAVELL, Richard A</creatorcontrib><title>Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Immune homeostasis is a delicate balance between the immune defense against foreign pathogens and suppression of the immune
system to maintain self-tolerance and prevent autoimmune disease. Maintenance of this balance involves several crucial networks
of cytokines and various cell types. Among these regulators, transforming growth factor-β (TGF-β) is a potent cytokine with
diverse effects on hematopoietic cells. Its pivotal function within the immune system is to maintain tolerance via the regulation
of lymphocyte proliferation, differentiation, and survival. In addition, TGF-β controls the initiation and resolution of inflammatory
responses through the regulation of chemotaxis and activation of leukocytes in the periphery, including lymphocytes, natural
killer cells, dendritic cells, macrophages, mast cells, and granulocytes. Through its pleiotropic effects on these immune
cells, TGF-β prevents the development of autoimmune diseases without compromising immune responses to pathogens. However,
overactivation of this pathway can lead to several immunopathologies under physiologic conditions including cancer progression,
making it an attractive target for antitumor therapies. This review discusses the biological functions of TGF-β and its effects
on the immune system and addresses how immunosuppression by this cytokine can promote tumorigenesis, providing the rationale
for evaluating the immune-enhancing and antitumor effects of inhibiting TGF-β in cancer patients.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Dendritic Cells - immunology</subject><subject>Humans</subject><subject>Immune Response</subject><subject>Killer Cells, Natural - immunology</subject><subject>Medical sciences</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - immunology</subject><subject>Pharmacology. Drug treatments</subject><subject>T-Lymphocytes - immunology</subject><subject>TGF-β</subject><subject>Transforming Growth Factor beta - antagonists & inhibitors</subject><subject>Transforming Growth Factor beta - physiology</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpFkMtq3DAUhkVoyP0RUrRpIAunOpZ1cXdhyA0ChTDdZCNk-Sh28a2Sh5DXyoP0mSIzE7KRdH6-_wg-Qs6BXQEI_ROY0hkreH61Wj1lTGUpVXvkCIRQGc-l-Jben8whOY7xL2NQACsOyCEorYQSxRF5Xgc7RD-Gvh1e6F0YX-eG3lo3jyH7_07tUNO5QfrQ95sB6RPGaRwi_krB1LXOzm0aaarT62FO8-Aw0HWDwU5vp2Tf2y7i2e4-IX9ub9ar--zx993D6voxc1zBnClknte1l7JimkNVcp3XHpzTuhaqKEVpncNSWqjRKesKJfMqnYozKXzl-Qm52O6dwvhvg3E2fRsddp0dcNxEI3WuVAkqgWILujDGGNCbKbS9DW8GmFmkmkWYWYSZJNUwtaRL7_vug03VY_3V2llMwI8dYKOznU9KXRu_uBJkwXKRuMst17QvzWsb0GyNBYxog2sMcAPaiFzm_ANHi49r</recordid><startdate>20070915</startdate><enddate>20070915</enddate><creator>WRZESINSKI, Stephen H</creator><creator>WAN, Yisong Y</creator><creator>FLAVELL, Richard A</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070915</creationdate><title>Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy</title><author>WRZESINSKI, Stephen H ; WAN, Yisong Y ; FLAVELL, Richard A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-7e0f3ddf66b0831b9382df1cc88d574959acce96a1dec7ac4762bc4773065fbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Dendritic Cells - immunology</topic><topic>Humans</topic><topic>Immune Response</topic><topic>Killer Cells, Natural - immunology</topic><topic>Medical sciences</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - immunology</topic><topic>Pharmacology. Drug treatments</topic><topic>T-Lymphocytes - immunology</topic><topic>TGF-β</topic><topic>Transforming Growth Factor beta - antagonists & inhibitors</topic><topic>Transforming Growth Factor beta - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WRZESINSKI, Stephen H</creatorcontrib><creatorcontrib>WAN, Yisong Y</creatorcontrib><creatorcontrib>FLAVELL, Richard A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WRZESINSKI, Stephen H</au><au>WAN, Yisong Y</au><au>FLAVELL, Richard A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2007-09-15</date><risdate>2007</risdate><volume>13</volume><issue>18</issue><spage>5262</spage><epage>5270</epage><pages>5262-5270</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Immune homeostasis is a delicate balance between the immune defense against foreign pathogens and suppression of the immune
system to maintain self-tolerance and prevent autoimmune disease. Maintenance of this balance involves several crucial networks
of cytokines and various cell types. Among these regulators, transforming growth factor-β (TGF-β) is a potent cytokine with
diverse effects on hematopoietic cells. Its pivotal function within the immune system is to maintain tolerance via the regulation
of lymphocyte proliferation, differentiation, and survival. In addition, TGF-β controls the initiation and resolution of inflammatory
responses through the regulation of chemotaxis and activation of leukocytes in the periphery, including lymphocytes, natural
killer cells, dendritic cells, macrophages, mast cells, and granulocytes. Through its pleiotropic effects on these immune
cells, TGF-β prevents the development of autoimmune diseases without compromising immune responses to pathogens. However,
overactivation of this pathway can lead to several immunopathologies under physiologic conditions including cancer progression,
making it an attractive target for antitumor therapies. This review discusses the biological functions of TGF-β and its effects
on the immune system and addresses how immunosuppression by this cytokine can promote tumorigenesis, providing the rationale
for evaluating the immune-enhancing and antitumor effects of inhibiting TGF-β in cancer patients.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>17875754</pmid><doi>10.1158/1078-0432.CCR-07-1157</doi><tpages>9</tpages></addata></record> |
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| ispartof | Clinical cancer research, 2007-09, Vol.13 (18), p.5262-5270 |
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| language | eng |
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| source | Freely Accessible Journals |
| subjects | Animals Antineoplastic agents Biological and medical sciences Dendritic Cells - immunology Humans Immune Response Killer Cells, Natural - immunology Medical sciences Neoplasms - drug therapy Neoplasms - immunology Pharmacology. Drug treatments T-Lymphocytes - immunology TGF-β Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - physiology |
| title | Transforming Growth Factor-β and the Immune Response: Implications for Anticancer Therapy |
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