Donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) after cord blood transplantation in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia

We report a case of donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) occurring after cord blood transplantation (CBT). A 41-year-old man developed precursor B-cell acute lymphoblastic leukemia with a karyotype of 46, XY, t(9;22)(q34;q11) and inv(9)(p11;q13), for which he r...

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Bibliographic Details
Published in:International journal of hematology 2007-08, Vol.86 (2), p.192-195
Main Authors: Mitsui, Hideki, Nakazawa, Tsuyoshi, Tanimura, Akira, Karasuno, Takahiro, Hiraoka, Akira
Format: Article
Language:English
Subjects:
Adult
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 7
Chronic Disease
Cord Blood Stem Cell Transplantation - adverse effects
Humans
Infant
Male
Myeloproliferative Disorders - etiology
Myeloproliferative Disorders - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Tissue Donors
Translocation, Genetic
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Summary:We report a case of donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) occurring after cord blood transplantation (CBT). A 41-year-old man developed precursor B-cell acute lymphoblastic leukemia with a karyotype of 46, XY, t(9;22)(q34;q11) and inv(9)(p11;q13), for which he received CBT from a sex-mismatched donor at the first complete remission of the leukemia. Five months after CBT, gradual neutrophilia of unknown origin developed following the myeloid reconstitution after CBT. Karyotyping of bone marrow cells at 9 months after CBT showed 46, XX, t(7;11)(p15;p15) in 17/20 dividing cells, but neither Philadelphia chromosome (Ph) nor inv(9)(p11;q13) was present. This is the first report of chronic myeloproliferative disease with t(7;11)(p15;p15) that developed in donor cells after CBT. The donor was well-developed and healthy, at least at the time of follow-up, half a year after the birth.
ISSN:0925-5710
1865-3774
DOI:10.1532/IJH97.06162