Association of IL-8 (−251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma

Summary Interleukin-8 (IL-8) is an angiogenic chemokine that plays a potent role in both development and progression of many human malignancies including nasopharyngeal carcinoma (NPC). In the present study, we evaluated the susceptibility and prognostic implications of the (−251) T/A genetic variat...

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Bibliographic Details
Published in:Human immunology 2007-09, Vol.68 (9), p.761-769
Main Authors: Nasr, Hela Ben, Chahed, Karim, Mestiri, Souhir, Bouaouina, Noureddine, Snoussi, Kaouther, Chouchane, Lotfi
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Carcinoma - diagnosis
Carcinoma - genetics
Carcinoma - pathology
Disease Progression
Female
Genetic Predisposition to Disease
Genetic susceptibility
Humans
IL-8
Interleukin-8 - metabolism
Male
Nasopharyngeal carcinoma
Nasopharyngeal Neoplasms - diagnosis
Nasopharyngeal Neoplasms - genetics
Nasopharyngeal Neoplasms - pathology
Neoplasm Invasiveness
Polymorphism
Polymorphism, Single Nucleotide
Prognosis
Promoter Regions, Genetic
Risk Factors
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Summary:Summary Interleukin-8 (IL-8) is an angiogenic chemokine that plays a potent role in both development and progression of many human malignancies including nasopharyngeal carcinoma (NPC). In the present study, we evaluated the susceptibility and prognostic implications of the (−251) T/A genetic variation in IL-8 in NPC. We used the allele-specific polymerase chain reaction to characterize the variation of the IL-8 promoter region for 160 unrelated Tunisian patients with NPC and 169 healthy control subjects. There was a significant association between the homozygotes IL-8 (−251) AA genotype and nasopharyngeal carcinoma (OR = 2.46; P = 0.004). The presence of the IL-8 (−251) AA genotype was highly associated with elevated NPC risk for male patients. A significant association was demonstrated between the IL-8 (−251) AA genotype and the aggressive forms of NPC as defined by large tumor size, lymph node metastasis, and advanced stages. Moreover, the presence of the IL-8 (−251) AA genotype indicated a significant association with decreased overall survival. Our findings suggest that the IL-8 promoter polymorphism is associated with increased nasopharyngeal carcinoma risk, particularly in males, as well as disease progress, supporting our hypothesis for IL-8 involvement in NPC pathogenesis.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2007.06.006