Mannose binding lectin gene polymorphisms are associated with type 1 diabetes in Brazilian children and adolescents

Summary Mannose-binding lectin is an important constituent of the innate immune system, the serum levels of which are greatly affected by polymorphisms of the MBL2 gene: three polymorphims in exon 1, as well as nucleotide variations in the promoter region of the gene, have been associated with prote...

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Bibliographic Details
Published in:Human immunology 2007-09, Vol.68 (9), p.739-743
Main Authors: Araujo, Jacqueline, Brandão, Lucas A.C, Guimarães, Rafael L, Santos, Sérgio, Falcão, Elcy A, Milanese, Michele, Segat, Ludovica, Souza, Paulo R, de Lima-Filho, José Luiz, Crovella, Sergio
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Allergy and Immunology
Brazil - epidemiology
Child
Child, Preschool
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - genetics
Female
Gene Frequency
Genotype
Humans
Infant
Male
Mannose-Binding Lectin - genetics
MBL2
Melting temperature assay
Polymorphism, Genetic
Polymorphisms
Type 1 diabetes
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Summary:Summary Mannose-binding lectin is an important constituent of the innate immune system, the serum levels of which are greatly affected by polymorphisms of the MBL2 gene: three polymorphims in exon 1, as well as nucleotide variations in the promoter region of the gene, have been associated with protein deficiency and some infectious and autoimmune disease. The aim of this study was to investigate a possible association between MBL2 gene polymorphisms in patients who have developed type 1 diabetes during childhood and adolescence. We evaluated MBL2 gene polymorphisms in 214 children and adolescents with type 1 diabetes and compared them with a healthy control group, finding significant differences in genotypic and allelic frequencies ( p = 0.004 and p = 0.0008, respectively). Our results suggest that patients with type 1 diabetes possessing the 0 allele have a higher risk for developing type 1 diabetes during childhood and adolescence, and that this risk factor is not related to age at diagnosis.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2007.05.007