CD46 Expression is Indicative of Shorter Revival-free Survival for Ovarian Cancer Patients

Background: The membrane cofactor protein CD46 represents a complement inhibitor, which protects autologous cells from complement - mediated cytotoxicity. CD46 may exhibit the potential to protect tumor cells from the immune responses of the host. The present study aimed to evaluate the prognostic s...

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Bibliographic Details
Published in:Anticancer research 2006-11, Vol.26 (6C), p.4943-4948
Main Authors: SUROWIAK, Pawel, MATERNA, Verena, MACIEJCZYK, Adam, KAPLENKO, Irina, SPACZYNSKI, Marek, DIETEL, Manfred, LAGE, Hermann, ZABEL, Maciej
Format: Article
Language:English
Subjects:
Biological and medical sciences
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Medical sciences
Membrane Cofactor Protein - biosynthesis
Middle Aged
Ovarian Neoplasms - immunology
Paraffin Embedding
Prognosis
Retrospective Studies
Tumors
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Summary:Background: The membrane cofactor protein CD46 represents a complement inhibitor, which protects autologous cells from complement - mediated cytotoxicity. CD46 may exhibit the potential to protect tumor cells from the immune responses of the host. The present study aimed to evaluate the prognostic significance of CD46 expression in ovarian cancers. Materials and Methods: The analyses were performed on 73 ovarian cancer samples. Immunohistochemical reactions were performed on paraffin sections of tumors using monoclonal antibodies directed against CD46. The immunohistochemical reactions and the clinical observations results were subjected to statistical analysis. Results: Expression of CD46 was demonstrated in 60% of primary laparotomy cases and in 70% secondary cytoreduction cases. Kaplan-Meier analysis showed that a significantly shorter revival-free time was linked to cases with CD46 expression at PL (p=0.01). Conclusion: Ovarian cancers manifest CD46 expression that is linked to a less favourable prognosis.
ISSN:0250-7005
1791-7530