Flavonoid glycosides from Prunus armeniaca and the antibacterial activity of a crude extract

Investigations on the chemical constituents of the fruits of Prunus armeniaca have led to the isolation of two new flavonoid glycosides, 4',5,7-trihydroxy flavone-7-O-[beta-D-mannopyranosyl (1'''-->2")]-beta-D-allopyranoside (1) and 3,4',5,7-tetrahydroxy-3',5�...

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Bibliographic Details
Published in:Archives of pharmacal research 2007-08, Vol.30 (8), p.932-937
Main Authors: Rashid, Fahima, Ahmed, Rehana, Mahmood, Azhar, Ahmad, Zaheer, Bibi, Nazia, Kazmi, Shahana Urooj
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Flavonoids - isolation & purification
Flavonoids - pharmacology
Fruit - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Prunus - chemistry
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Summary:Investigations on the chemical constituents of the fruits of Prunus armeniaca have led to the isolation of two new flavonoid glycosides, 4',5,7-trihydroxy flavone-7-O-[beta-D-mannopyranosyl (1'''-->2")]-beta-D-allopyranoside (1) and 3,4',5,7-tetrahydroxy-3',5'-di-methoxy flavone 3-O-[alpha-L-rhamnopyranosyl (1'''-->6")]-beta-D-galactopyranoside (2), from the butanolic fraction of the fruits. The butanolic extract exhibited antibacterial activity against both Gram positive and Gram negative bacteria. The structures of these compounds were elucidated through spectral studies, including 2D-NMR (COSY, NOESY, J-resolved), HMQC and HMBC experiments.
ISSN:0253-6269
DOI:10.1007/BF02993959