TFIIB and the regulation of transcription by RNA polymerase II

Accurate transcription of a gene by RNA polymerase II requires the assembly of a group of general transcription factors at the promoter. The general transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA polymerase I...

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Bibliographic Details
Published in:Chromosoma 2007-10, Vol.116 (5), p.417-429
Main Authors: Deng, Wensheng, Roberts, Stefan G. E
Format: Article
Language:English
Subjects:
Animals
Gene Expression Regulation
Humans
Proteins
RNA polymerase
RNA Polymerase II - metabolism
Transcription Factor TFIIB - chemistry
Transcription Factor TFIIB - metabolism
Transcription, Genetic
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Summary:Accurate transcription of a gene by RNA polymerase II requires the assembly of a group of general transcription factors at the promoter. The general transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA polymerase II. TFIIB makes extensive contact with the core promoter via two independent DNA-recognition modules. In addition to interacting with other general transcription factors, TFIIB directly modulates the catalytic center of RNA polymerase II in the transcription complex. Moreover, TFIIB has been proposed as a target of transcriptional activator proteins that act to stimulate preinitiation complex assembly. In this review, we will discuss our current understanding of these activities of TFIIB.
ISSN:0009-5915
1432-0886
DOI:10.1007/s00412-007-0113-9