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Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis
Bioassay-guided fractionation of an active fraction from an extract of a marine starfish, Novodinia antillensis, led to the identification of two new saponins, Sch 725737 ( 1) and Sch 725739 ( 2). Compound 1 was identified as the NaV1.8 inhibitor with IC 50 of ∼9 μM. Bioassay-guided fractionation of...
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| Published in: | Bioorganic & medicinal chemistry letters 2007-10, Vol.17 (20), p.5543-5547 |
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| Main Authors: | , , , , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c475t-1e2fd2ca8c03af4b28894bf2f2154667ba4b7ce9bb4ba2c4634b1038b9f70b623 |
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| cites | cdi_FETCH-LOGICAL-c475t-1e2fd2ca8c03af4b28894bf2f2154667ba4b7ce9bb4ba2c4634b1038b9f70b623 |
| container_end_page | 5547 |
| container_issue | 20 |
| container_start_page | 5543 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 17 |
| creator | Yang, Shu-Wei Chan, Tze-Ming Buevich, Alexei Priestley, Tony Crona, James Reed, John Wright, Amy E. Patel, Mahesh Gullo, Vincent Chen, Guodong Pramanik, Birendra Chu, Min |
| description | Bioassay-guided fractionation of an active fraction from an extract of a marine starfish,
Novodinia antillensis, led to the identification of two new saponins, Sch 725737 (
1) and Sch 725739 (
2). Compound
1 was identified as the NaV1.8 inhibitor with IC
50 of ∼9
μM.
Bioassay-guided fractionation of an active fraction from an extract of a marine starfish,
Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (
1) and Sch 725739 (
2). Compound
1 was identified as the NaV1.8 inhibitor with IC
50 of ∼9
μM. The purification and the structure elucidation of these two saponins are described. |
| doi_str_mv | 10.1016/j.bmcl.2007.08.025 |
| format | article |
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Novodinia antillensis, led to the identification of two new saponins, Sch 725737 (
1) and Sch 725739 (
2). Compound
1 was identified as the NaV1.8 inhibitor with IC
50 of ∼9
μM.
Bioassay-guided fractionation of an active fraction from an extract of a marine starfish,
Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (
1) and Sch 725739 (
2). Compound
1 was identified as the NaV1.8 inhibitor with IC
50 of ∼9
μM. The purification and the structure elucidation of these two saponins are described.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2007.08.025</identifier><identifier>PMID: 17804230</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Carbohydrate Sequence ; General pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Membrane Potentials - drug effects ; NaV1.8 sodium channel ; Novodinia antillensis ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Saponin ; Saponins - chemistry ; Saponins - isolation & purification ; Saponins - pharmacology ; Sch 725737 ; Sch 725739 ; Sodium Channel Blockers - chemistry ; Sodium Channel Blockers - isolation & purification ; Sodium Channel Blockers - pharmacology ; Sodium Channels - metabolism ; Starfish ; Starfish - chemistry ; Steroids - chemistry ; Steroids - isolation & purification ; Steroids - pharmacology</subject><ispartof>Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5543-5547</ispartof><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-1e2fd2ca8c03af4b28894bf2f2154667ba4b7ce9bb4ba2c4634b1038b9f70b623</citedby><cites>FETCH-LOGICAL-c475t-1e2fd2ca8c03af4b28894bf2f2154667ba4b7ce9bb4ba2c4634b1038b9f70b623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19109513$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17804230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Shu-Wei</creatorcontrib><creatorcontrib>Chan, Tze-Ming</creatorcontrib><creatorcontrib>Buevich, Alexei</creatorcontrib><creatorcontrib>Priestley, Tony</creatorcontrib><creatorcontrib>Crona, James</creatorcontrib><creatorcontrib>Reed, John</creatorcontrib><creatorcontrib>Wright, Amy E.</creatorcontrib><creatorcontrib>Patel, Mahesh</creatorcontrib><creatorcontrib>Gullo, Vincent</creatorcontrib><creatorcontrib>Chen, Guodong</creatorcontrib><creatorcontrib>Pramanik, Birendra</creatorcontrib><creatorcontrib>Chu, Min</creatorcontrib><title>Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Bioassay-guided fractionation of an active fraction from an extract of a marine starfish,
Novodinia antillensis, led to the identification of two new saponins, Sch 725737 (
1) and Sch 725739 (
2). Compound
1 was identified as the NaV1.8 inhibitor with IC
50 of ∼9
μM.
Bioassay-guided fractionation of an active fraction from an extract of a marine starfish,
Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (
1) and Sch 725739 (
2). Compound
1 was identified as the NaV1.8 inhibitor with IC
50 of ∼9
μM. The purification and the structure elucidation of these two saponins are described.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbohydrate Sequence</subject><subject>General pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Membrane Potentials - drug effects</subject><subject>NaV1.8 sodium channel</subject><subject>Novodinia antillensis</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Saponin</subject><subject>Saponins - chemistry</subject><subject>Saponins - isolation & purification</subject><subject>Saponins - pharmacology</subject><subject>Sch 725737</subject><subject>Sch 725739</subject><subject>Sodium Channel Blockers - chemistry</subject><subject>Sodium Channel Blockers - isolation & purification</subject><subject>Sodium Channel Blockers - pharmacology</subject><subject>Sodium Channels - metabolism</subject><subject>Starfish</subject><subject>Starfish - chemistry</subject><subject>Steroids - chemistry</subject><subject>Steroids - isolation & purification</subject><subject>Steroids - pharmacology</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kE1r3DAQhkVpaDYff6CH4kt7WjsjWbZs6CWEfEFIDkkgNyHJI6LFlraSN9B_Hy27sLecRgPP-zJ6CPlJoaJA24tVpSczVgxAVNBVwJpvZEF5y8uaQ_OdLKBvoex6_nZMTlJaAVAOnP8gx1R0wFkNC6IfwweORZoxBjeo_FLr4J1Py-LZvBeCNaIWhfLDYe2XhY1hKlQxqeg85rCK1qX3ZZHLwuC8Uzkxu3FEn1w6I0dWjQnP9_OUvN5cv1zdlQ9Pt_dXlw-l4aKZS4rMDsyozkCtLNesy5dryyyjDW9boRXXwmCvNdeKGd7WXFOoO91bAbpl9Sn5s-tdx_Bvg2mWk0sGx1F5DJsk2y5XNs0WZDvQxJBSRCvX0eW__JcU5NasXMmtWbk1K6GT2WwO_dq3b_SEwyGyV5mB33tAJaNGG5U3Lh24nkLf0Dpzf3ccZhcfDqNMxqE3OLiIZpZDcF_d8QklGJTv</recordid><startdate>20071015</startdate><enddate>20071015</enddate><creator>Yang, Shu-Wei</creator><creator>Chan, Tze-Ming</creator><creator>Buevich, Alexei</creator><creator>Priestley, Tony</creator><creator>Crona, James</creator><creator>Reed, John</creator><creator>Wright, Amy E.</creator><creator>Patel, Mahesh</creator><creator>Gullo, Vincent</creator><creator>Chen, Guodong</creator><creator>Pramanik, Birendra</creator><creator>Chu, Min</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071015</creationdate><title>Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis</title><author>Yang, Shu-Wei ; Chan, Tze-Ming ; Buevich, Alexei ; Priestley, Tony ; Crona, James ; Reed, John ; Wright, Amy E. ; Patel, Mahesh ; Gullo, Vincent ; Chen, Guodong ; Pramanik, Birendra ; Chu, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-1e2fd2ca8c03af4b28894bf2f2154667ba4b7ce9bb4ba2c4634b1038b9f70b623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbohydrate Sequence</topic><topic>General pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Membrane Potentials - drug effects</topic><topic>NaV1.8 sodium channel</topic><topic>Novodinia antillensis</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Saponin</topic><topic>Saponins - chemistry</topic><topic>Saponins - isolation & purification</topic><topic>Saponins - pharmacology</topic><topic>Sch 725737</topic><topic>Sch 725739</topic><topic>Sodium Channel Blockers - chemistry</topic><topic>Sodium Channel Blockers - isolation & purification</topic><topic>Sodium Channel Blockers - pharmacology</topic><topic>Sodium Channels - metabolism</topic><topic>Starfish</topic><topic>Starfish - chemistry</topic><topic>Steroids - chemistry</topic><topic>Steroids - isolation & purification</topic><topic>Steroids - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Shu-Wei</creatorcontrib><creatorcontrib>Chan, Tze-Ming</creatorcontrib><creatorcontrib>Buevich, Alexei</creatorcontrib><creatorcontrib>Priestley, Tony</creatorcontrib><creatorcontrib>Crona, James</creatorcontrib><creatorcontrib>Reed, John</creatorcontrib><creatorcontrib>Wright, Amy E.</creatorcontrib><creatorcontrib>Patel, Mahesh</creatorcontrib><creatorcontrib>Gullo, Vincent</creatorcontrib><creatorcontrib>Chen, Guodong</creatorcontrib><creatorcontrib>Pramanik, Birendra</creatorcontrib><creatorcontrib>Chu, Min</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Shu-Wei</au><au>Chan, Tze-Ming</au><au>Buevich, Alexei</au><au>Priestley, Tony</au><au>Crona, James</au><au>Reed, John</au><au>Wright, Amy E.</au><au>Patel, Mahesh</au><au>Gullo, Vincent</au><au>Chen, Guodong</au><au>Pramanik, Birendra</au><au>Chu, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2007-10-15</date><risdate>2007</risdate><volume>17</volume><issue>20</issue><spage>5543</spage><epage>5547</epage><pages>5543-5547</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Bioassay-guided fractionation of an active fraction from an extract of a marine starfish,
Novodinia antillensis, led to the identification of two new saponins, Sch 725737 (
1) and Sch 725739 (
2). Compound
1 was identified as the NaV1.8 inhibitor with IC
50 of ∼9
μM.
Bioassay-guided fractionation of an active fraction from an extract of a marine starfish,
Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (
1) and Sch 725739 (
2). Compound
1 was identified as the NaV1.8 inhibitor with IC
50 of ∼9
μM. The purification and the structure elucidation of these two saponins are described.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17804230</pmid><doi>10.1016/j.bmcl.2007.08.025</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5543-5547 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68288552 |
| source | ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Carbohydrate Sequence General pharmacology Magnetic Resonance Spectroscopy Medical sciences Membrane Potentials - drug effects NaV1.8 sodium channel Novodinia antillensis Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Saponin Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Sch 725737 Sch 725739 Sodium Channel Blockers - chemistry Sodium Channel Blockers - isolation & purification Sodium Channel Blockers - pharmacology Sodium Channels - metabolism Starfish Starfish - chemistry Steroids - chemistry Steroids - isolation & purification Steroids - pharmacology |
| title | Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis |
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