Survival Markers Related to Bone Metastases in Prostate Cancer

Prognostic value of a bone resorption marker, tartrate-resistant acid phosphatase isoform 5b (TRACP 5b), and two matrix metalloproteinases (MMP-2 and MMP-9) was compared with the standard clinical analyses of total alkaline phosphatase (tALP) and prostate-specific antigen (PSA), in prostate cancer (...

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Bibliographic Details
Published in:Anticancer research 2006-11, Vol.26 (6C), p.4879-4884
Main Authors: SALMINEN, E. K, KALLIOINEN, M. J, ALA-HOUHALA, M. A, VIHINEN, P. P, TIITINEN, S. L, VARPULA, M, VAHLBERG, T. J
Format: Article
Language:English
Subjects:
Acid Phosphatase - blood
Aged
Aged, 80 and over
Alkaline Phosphatase - blood
Biological and medical sciences
Biomarkers, Tumor - blood
Bone Neoplasms - blood
Bone Neoplasms - enzymology
Bone Neoplasms - secondary
Cross-Sectional Studies
Diseases of the osteoarticular system
Humans
Isoenzymes - blood
Male
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 9 - blood
Medical sciences
Middle Aged
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - enzymology
Prostatic Neoplasms - pathology
ROC Curve
Tartrate-Resistant Acid Phosphatase
Tumors
Tumors of striated muscle and skeleton
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Summary:Prognostic value of a bone resorption marker, tartrate-resistant acid phosphatase isoform 5b (TRACP 5b), and two matrix metalloproteinases (MMP-2 and MMP-9) was compared with the standard clinical analyses of total alkaline phosphatase (tALP) and prostate-specific antigen (PSA), in prostate cancer (PC) patients with (BM+) or without (BM-) bone metastases. Diagnostic accuracy evaluation showed the highest area under the curve for tALP (AUC=0.98), followed by PSA (AUC=0.87), TRACP 5b (AUC=0.82), MMP-9 (AUC=0.62) and MMP-2 (AUC=0.53). Significantly shorter survival was observed for patients with tALP (p
ISSN:0250-7005
1791-7530