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Survival Markers Related to Bone Metastases in Prostate Cancer
Prognostic value of a bone resorption marker, tartrate-resistant acid phosphatase isoform 5b (TRACP 5b), and two matrix metalloproteinases (MMP-2 and MMP-9) was compared with the standard clinical analyses of total alkaline phosphatase (tALP) and prostate-specific antigen (PSA), in prostate cancer (...
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| Published in: | Anticancer research 2006-11, Vol.26 (6C), p.4879-4884 |
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| container_end_page | 4884 |
| container_issue | 6C |
| container_start_page | 4879 |
| container_title | Anticancer research |
| container_volume | 26 |
| creator | SALMINEN, E. K KALLIOINEN, M. J ALA-HOUHALA, M. A VIHINEN, P. P TIITINEN, S. L VARPULA, M VAHLBERG, T. J |
| description | Prognostic value of a bone resorption marker, tartrate-resistant acid phosphatase isoform 5b (TRACP 5b), and two matrix metalloproteinases
(MMP-2 and MMP-9) was compared with the standard clinical analyses of total alkaline phosphatase (tALP) and prostate-specific
antigen (PSA), in prostate cancer (PC) patients with (BM+) or without (BM-) bone metastases. Diagnostic accuracy evaluation
showed the highest area under the curve for tALP (AUC=0.98), followed by PSA (AUC=0.87), TRACP 5b (AUC=0.82), MMP-9 (AUC=0.62)
and MMP-2 (AUC=0.53). Significantly shorter survival was observed for patients with tALP (p |
| format | article |
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(MMP-2 and MMP-9) was compared with the standard clinical analyses of total alkaline phosphatase (tALP) and prostate-specific
antigen (PSA), in prostate cancer (PC) patients with (BM+) or without (BM-) bone metastases. Diagnostic accuracy evaluation
showed the highest area under the curve for tALP (AUC=0.98), followed by PSA (AUC=0.87), TRACP 5b (AUC=0.82), MMP-9 (AUC=0.62)
and MMP-2 (AUC=0.53). Significantly shorter survival was observed for patients with tALP (p<0.001), TRACP 5b (p=0.002) and
PSA (p<0.001) levels, above the determined cut-off values compared with lower marker levels. In multivariate Cox regression
analysis, only tALP and PSA, in addition to Gleason score were independent prognostic factors for survival. Of the three novel
markers tested, only TRACP 5b proved to be predictive of survival in PC with bone metastases. MMP-2 and -9 are thus not recommended
for further studies in this context.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 17214355</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Acid Phosphatase - blood ; Aged ; Aged, 80 and over ; Alkaline Phosphatase - blood ; Biological and medical sciences ; Biomarkers, Tumor - blood ; Bone Neoplasms - blood ; Bone Neoplasms - enzymology ; Bone Neoplasms - secondary ; Cross-Sectional Studies ; Diseases of the osteoarticular system ; Humans ; Isoenzymes - blood ; Male ; Matrix Metalloproteinase 2 - blood ; Matrix Metalloproteinase 9 - blood ; Medical sciences ; Middle Aged ; Prostate-Specific Antigen - blood ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - enzymology ; Prostatic Neoplasms - pathology ; ROC Curve ; Tartrate-Resistant Acid Phosphatase ; Tumors ; Tumors of striated muscle and skeleton</subject><ispartof>Anticancer research, 2006-11, Vol.26 (6C), p.4879-4884</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18373670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17214355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SALMINEN, E. K</creatorcontrib><creatorcontrib>KALLIOINEN, M. J</creatorcontrib><creatorcontrib>ALA-HOUHALA, M. A</creatorcontrib><creatorcontrib>VIHINEN, P. P</creatorcontrib><creatorcontrib>TIITINEN, S. L</creatorcontrib><creatorcontrib>VARPULA, M</creatorcontrib><creatorcontrib>VAHLBERG, T. J</creatorcontrib><title>Survival Markers Related to Bone Metastases in Prostate Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Prognostic value of a bone resorption marker, tartrate-resistant acid phosphatase isoform 5b (TRACP 5b), and two matrix metalloproteinases
(MMP-2 and MMP-9) was compared with the standard clinical analyses of total alkaline phosphatase (tALP) and prostate-specific
antigen (PSA), in prostate cancer (PC) patients with (BM+) or without (BM-) bone metastases. Diagnostic accuracy evaluation
showed the highest area under the curve for tALP (AUC=0.98), followed by PSA (AUC=0.87), TRACP 5b (AUC=0.82), MMP-9 (AUC=0.62)
and MMP-2 (AUC=0.53). Significantly shorter survival was observed for patients with tALP (p<0.001), TRACP 5b (p=0.002) and
PSA (p<0.001) levels, above the determined cut-off values compared with lower marker levels. In multivariate Cox regression
analysis, only tALP and PSA, in addition to Gleason score were independent prognostic factors for survival. Of the three novel
markers tested, only TRACP 5b proved to be predictive of survival in PC with bone metastases. MMP-2 and -9 are thus not recommended
for further studies in this context.</description><subject>Acid Phosphatase - blood</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alkaline Phosphatase - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Bone Neoplasms - blood</subject><subject>Bone Neoplasms - enzymology</subject><subject>Bone Neoplasms - secondary</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of the osteoarticular system</subject><subject>Humans</subject><subject>Isoenzymes - blood</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - blood</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - enzymology</subject><subject>Prostatic Neoplasms - pathology</subject><subject>ROC Curve</subject><subject>Tartrate-Resistant Acid Phosphatase</subject><subject>Tumors</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpFz11LwzAUBuAgipvTvyC50btCmjRfN4IWp8KGorsPWXPqomk7k3biv7fgZHDgcODhPbxHaJpLnWeSM3KMpoRykklC-ASdpfRBiBBasVM0ySXNC8b5FN28DXHndzbgpY2fEBN-hWB7cLjv8F3XAl5Cb9M4kLBv8UvsxqMHXNq2gniOTmobElzs9wyt5ver8jFbPD88lbeLbEMl6TNHrSAgeF1oVZE1UYXWjjqgjBNegATFoGZrmlf5CCgrhHNKcylZLmrm2Axd_8VuY_c1QOpN41MFIdgWuiEZoahSnKsRXu7hsG7AmW30jY0_5r_wCK72wKbKhjqONXw6OMUkE5IcPm78--bbRzCpsSGMsczYSIURpSmU1OwX0Uxq_w</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>SALMINEN, E. K</creator><creator>KALLIOINEN, M. J</creator><creator>ALA-HOUHALA, M. A</creator><creator>VIHINEN, P. P</creator><creator>TIITINEN, S. L</creator><creator>VARPULA, M</creator><creator>VAHLBERG, T. J</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Survival Markers Related to Bone Metastases in Prostate Cancer</title><author>SALMINEN, E. K ; KALLIOINEN, M. J ; ALA-HOUHALA, M. A ; VIHINEN, P. P ; TIITINEN, S. L ; VARPULA, M ; VAHLBERG, T. 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K</creatorcontrib><creatorcontrib>KALLIOINEN, M. J</creatorcontrib><creatorcontrib>ALA-HOUHALA, M. A</creatorcontrib><creatorcontrib>VIHINEN, P. P</creatorcontrib><creatorcontrib>TIITINEN, S. L</creatorcontrib><creatorcontrib>VARPULA, M</creatorcontrib><creatorcontrib>VAHLBERG, T. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SALMINEN, E. K</au><au>KALLIOINEN, M. J</au><au>ALA-HOUHALA, M. A</au><au>VIHINEN, P. P</au><au>TIITINEN, S. L</au><au>VARPULA, M</au><au>VAHLBERG, T. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival Markers Related to Bone Metastases in Prostate Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>26</volume><issue>6C</issue><spage>4879</spage><epage>4884</epage><pages>4879-4884</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Prognostic value of a bone resorption marker, tartrate-resistant acid phosphatase isoform 5b (TRACP 5b), and two matrix metalloproteinases
(MMP-2 and MMP-9) was compared with the standard clinical analyses of total alkaline phosphatase (tALP) and prostate-specific
antigen (PSA), in prostate cancer (PC) patients with (BM+) or without (BM-) bone metastases. Diagnostic accuracy evaluation
showed the highest area under the curve for tALP (AUC=0.98), followed by PSA (AUC=0.87), TRACP 5b (AUC=0.82), MMP-9 (AUC=0.62)
and MMP-2 (AUC=0.53). Significantly shorter survival was observed for patients with tALP (p<0.001), TRACP 5b (p=0.002) and
PSA (p<0.001) levels, above the determined cut-off values compared with lower marker levels. In multivariate Cox regression
analysis, only tALP and PSA, in addition to Gleason score were independent prognostic factors for survival. Of the three novel
markers tested, only TRACP 5b proved to be predictive of survival in PC with bone metastases. MMP-2 and -9 are thus not recommended
for further studies in this context.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17214355</pmid><tpages>6</tpages></addata></record> |
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| subjects | Acid Phosphatase - blood Aged Aged, 80 and over Alkaline Phosphatase - blood Biological and medical sciences Biomarkers, Tumor - blood Bone Neoplasms - blood Bone Neoplasms - enzymology Bone Neoplasms - secondary Cross-Sectional Studies Diseases of the osteoarticular system Humans Isoenzymes - blood Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 9 - blood Medical sciences Middle Aged Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology ROC Curve Tartrate-Resistant Acid Phosphatase Tumors Tumors of striated muscle and skeleton |
| title | Survival Markers Related to Bone Metastases in Prostate Cancer |
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