Xenotransplantation of cryopreserved equine squamous cell carcinoma to athymic nude and SCID mice

Cryopreserved equine ocular squamous cell carcinoma (SCC) was inoculated subcutaneously into 15 athymic nude and 15 SCID mice. Xenotransplantation resulted in tumor growth in two athymic nude mice and 1 SCID mouse. Histological appearance and immunohistochemical characterization using cytokeratin 5/...

Full description

Saved in:
Bibliographic Details
Published in:Research in veterinary science 2007-12, Vol.83 (3), p.355-359
Main Authors: Ota, J., Giuliano, E.A., Mullen, S.F., Turk, J.R., Lewis, M.R., Cohn, L.A., Moore, C.P., Critser, J.
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - veterinary
Cryopreservation
Cryopreservation - veterinary
Equine
Graft Survival - physiology
Horse
Horse Diseases - pathology
Horses
Mice
Mice, Nude
Mice, SCID
Neoplasms, Experimental
Nude mice
SCID mice
Squamous cell carcinoma
Transplantation, Heterologous
Veterinary medicine
Xenotransplantation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cryopreserved equine ocular squamous cell carcinoma (SCC) was inoculated subcutaneously into 15 athymic nude and 15 SCID mice. Xenotransplantation resulted in tumor growth in two athymic nude mice and 1 SCID mouse. Histological appearance and immunohistochemical characterization using cytokeratin 5/6 markers and p53 markers of the tumor grown in mice was in full accord with the original equine tumors. No evidence of metastasis was noted in any mouse. This model may serve as a relevant in vivo model for studying the biology of equine ocular SCC and for the testing of new therapeutic modalities.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2006.11.016