IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children

• Published in: International journal of immunopathology and pharmacology 2007-07, Vol.20 (3), p.467-472
• Main Authors: Bodini, A., D'Orazio, C., Peroni, D.G., Corradi, M., Zerman, L., Folesani, G., Assael, B.M., Boner, A.L., Piacentini, G.L.
• Format: Article
• Language: English
• Subjects: Adolescent; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Bacterial Infections - complications; Bacterial Infections - drug therapy; Bacterial Infections - immunology; Bacterial Infections - microbiology; Biomarkers - analysis; Breath Tests; Child; Child, Preschool; Cystic Fibrosis - complications; Cystic Fibrosis - drug therapy; Cystic Fibrosis - immunology; Cystic Fibrosis - microbiology; Humans; Hydrogen-Ion Concentration; Interleukin-8 - analysis; Interleukin-8 - immunology; Respiratory Function Tests; Respiratory Tract Infections - complications; Respiratory Tract Infections - drug therapy; Respiratory Tract Infections - immunology; Respiratory Tract Infections - microbiology
• ISSN: 0394-6320; 2058-7384
• DOI: 10.1177/039463200702000305

Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidification. The aim of our study is to investigate whether IL-8 and pH levels in EBC of cystic fibrosis (CF) children with respiratory exacerbations change after antibiotic treatment. Lung function, IL-8 and pH EBC values were measured in fifteen CF children (mean age 11 years) with acute exacerbation before (T0) and after two weeks (T1) of antibiotic treatment. IL-8 and pH values were compared by paired t-test. A p