Comparison of Frequency of Coronary Spasm in Korean Patients With Versus Without Myocardial Bridging

• Published in: The American journal of cardiology 2007-10, Vol.100 (7), p.1083-1086
• Main Authors: Kim, Jin Won, MD, PhD, Park, Chang Gyu, MD, PhD, Suh, Soon Yong, MD, Choi, Cheol Ung, MD, Kim, Eung Joo, MD, PhD, Rha, Seung-Woon, MD, PhD, Seo, Hong Seog, MD, PhD, Oh, Dong Joo, MD, PhD
• Format: Article
• Language: English
• Subjects: Acetylcholine - administration & dosage; Asian people; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Case-Control Studies; Comparative studies; Coronary Angiography; Coronary heart disease; Coronary Vasospasm - diagnostic imaging; Coronary Vasospasm - etiology; Coronary vessels; Coronary Vessels - drug effects; Endothelium, Vascular - drug effects; Female; Heart; Heart Defects, Congenital - complications; Heart Defects, Congenital - diagnostic imaging; Humans; Korea; Male; Medical imaging; Medical sciences; Middle Aged; Myocardium - pathology; Risk Factors
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2007.05.030

The longstanding compression-relaxation effects of myocardial bridging may produce endothelial dysfunction by direct stress on the endothelium. We tested the hypothesis that myocardial bridging induces endothelial dysfunction and subsequently increases the risk of coronary spasm and investigated the symptomatic response to medication in patients with documented myocardial bridging and coronary spasm. In 81 patients with myocardial bridging (44 men; mean age 57.2 years) and 195 control patients without bridging and atherosclerotic lesions confirmed by angiography (97 men; mean age 58.4 years), spasm provocation testing was done by incremental acetylcholine infusion into the left coronary artery. Spasm was documented in 62 of 81 patients with bridging and in 31 of 195 controls (p