BK virus genotype distribution offers information of tracing the geographical origins of unidentified cadaver

Abstract There are no efficient methods to determine the geographic origin of unidentified cadavers. We showed earlier that the geographical distribution of the JC virus genotype detected from human kidneys indicates the host's geographical origin. As there are still cadavers from which we cann...

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Published in:Forensic science international 2007-11, Vol.173 (1), p.41-46
Main Authors: Ikegaya, Hiroshi, Motani, Hisako, Saukko, Pekka, Sato, Keita, Akutsu, Tomoko, Sakurada, Koichi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
BK virus
BK Virus - genetics
BK Virus - isolation & purification
Cadaver
Child
Deoxyribonucleic acid
DNA
DNA, Viral - isolation & purification
Female
Forensic Genetics - methods
Forensic medicine
Forensic sciences
General aspects
Genomes
Genotype
Genotype & phenotype
Geographical identification
Geography
Humans
Investigative techniques, diagnostic techniques (general aspects)
JC virus
Kidney
Kidney - virology
Kidneys
Male
Medical sciences
Methods
Middle Aged
Pathology
Plasmids
Polymerase Chain Reaction
Public health. Hygiene
Public health. Hygiene-occupational medicine
Sequence Analysis, DNA
Unidentified cadaver
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Akutsu, Tomoko
Sakurada, Koichi
description Abstract There are no efficient methods to determine the geographic origin of unidentified cadavers. We showed earlier that the geographical distribution of the JC virus genotype detected from human kidneys indicates the host's geographical origin. As there are still cadavers from which we cannot detect the JC virus (JCV), we investigated whether the genotype of another virus species belonging to the same family, human BK virus (BKV), could also be used to detect human geographical origin. BKV was found in 11 of 36 cases (30.5%). Even in the seven JCV-negative cases, the host's geographic origin could be estimated from the BKV genotype. Four subjects were positive for both the BKV and JCV. As the distribution areas of BKV and JCV genotypes are not identical, it is possible to narrow down the geographic area that any cadaver originates from.
doi_str_mv 10.1016/j.forsciint.2007.01.022
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We showed earlier that the geographical distribution of the JC virus genotype detected from human kidneys indicates the host's geographical origin. As there are still cadavers from which we cannot detect the JC virus (JCV), we investigated whether the genotype of another virus species belonging to the same family, human BK virus (BKV), could also be used to detect human geographical origin. BKV was found in 11 of 36 cases (30.5%). Even in the seven JCV-negative cases, the host's geographic origin could be estimated from the BKV genotype. Four subjects were positive for both the BKV and JCV. 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We showed earlier that the geographical distribution of the JC virus genotype detected from human kidneys indicates the host's geographical origin. As there are still cadavers from which we cannot detect the JC virus (JCV), we investigated whether the genotype of another virus species belonging to the same family, human BK virus (BKV), could also be used to detect human geographical origin. BKV was found in 11 of 36 cases (30.5%). Even in the seven JCV-negative cases, the host's geographic origin could be estimated from the BKV genotype. Four subjects were positive for both the BKV and JCV. 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identifier ISSN: 0379-0738
ispartof Forensic science international, 2007-11, Vol.173 (1), p.41-46
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1872-6283
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source ScienceDirect Journals
subjects Adult
Aged
Aged, 80 and over
Biological and medical sciences
BK virus
BK Virus - genetics
BK Virus - isolation & purification
Cadaver
Child
Deoxyribonucleic acid
DNA
DNA, Viral - isolation & purification
Female
Forensic Genetics - methods
Forensic medicine
Forensic sciences
General aspects
Genomes
Genotype
Genotype & phenotype
Geographical identification
Geography
Humans
Investigative techniques, diagnostic techniques (general aspects)
JC virus
Kidney
Kidney - virology
Kidneys
Male
Medical sciences
Methods
Middle Aged
Pathology
Plasmids
Polymerase Chain Reaction
Public health. Hygiene
Public health. Hygiene-occupational medicine
Sequence Analysis, DNA
Unidentified cadaver
title BK virus genotype distribution offers information of tracing the geographical origins of unidentified cadaver
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