Comparison of immune and adverse effects induced by AdjuVac and Freund's complete adjuvant in New Zealand white rabbits (Oryctolagus cuniculus)

Though Freund's complete adjuvant effectively increases immune response to vaccines in various species, its potentially severe inflammatory effects have led many animal researchers to seek alternative immunological adjuvants. In a study of New Zealand white rabbits, the authors compared the imm...

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Bibliographic Details
Published in:Lab animal 2007-10, Vol.36 (9), p.51-58
Main Authors: Powers, J.G, Nash, P.B, Rhyan, J.C, Yoder, C.A, Miller, L.A
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - adverse effects
Adjuvants, Immunologic - pharmacology
Adjuvants, Pharmaceutic
adverse effects
Animal Models
Animal models in research
Animals
Antibodies - blood
antibody formation
Biomedical and Life Sciences
Complications and side effects
Drug therapy
Female
Freund's Adjuvant - adverse effects
Freund's Adjuvant - pharmacology
Gonadotropin-Releasing Hormone - immunology
Health aspects
Immune response
inflammation
injection site
intramuscular injection
laboratory animals
lesions (animal)
Life Sciences
Mycobacteria
Mycobacterium
Oryctolagus cuniculus
Physiological aspects
Rabbits
Rabbits - immunology
research-note
vaccination
Vaccination - methods
Vaccination - veterinary
vaccine adjuvants
Veterinary Medicine/Veterinary Science
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Summary:Though Freund's complete adjuvant effectively increases immune response to vaccines in various species, its potentially severe inflammatory effects have led many animal researchers to seek alternative immunological adjuvants. In a study of New Zealand white rabbits, the authors compared the immune and adverse effects of Freund's complete adjuvant with the effects of two formulations of AdjuVac, an immunological adjuvant previously developed by their group. All three adjuvants improved humoral immune response but also caused inflammation. Inflammatory reactions caused by AdjuVac, however, tended to be less severe than those caused by Freund's complete adjuvant.
ISSN:0093-7355
1548-4475
DOI:10.1038/laban1007-51