Mild peripheral neuropathy prevents both leg muscular ischaemia and activation of exercise-induced coagulation in Type 2 diabetic patients with peripheral artery disease

• Published in: Diabetic medicine 2007-10, Vol.24 (10), p.1099-1104
• Main Authors: Piarulli, F., Sambataro, M., Minicuci, N., Scarano, L., Laverda, B., Baiocchi, M. R., Baldo-Enzi, G., Galasso, S., Bax, G., Fedele, D.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Blood Coagulation - physiology; coagulation; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - therapy; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - complications; Diabetic Angiopathies - physiopathology; Diabetic Neuropathies - complications; Diabetic Neuropathies - physiopathology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; intermittent claudication; Intermittent Claudication - etiology; Ischemia - physiopathology; Male; Medical sciences; Middle Aged; Muscle, Skeletal - blood supply; Outcome Assessment (Health Care); Peripheral Nervous System Diseases - etiology; Peripheral Nervous System Diseases - physiopathology; peripheral neuropathy; Risk Factors; treadmill test; type 2 diabetes; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Walking
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2007.02237.x

Aim  To study the influence of peripheral neuropathy on intermittent claudication in patients with Type 2 diabetes (T2DM). Methods  Twenty‐five patients with T2DM were grouped according to the ankle/brachial index (ABI): 10 with ABI > 0.9 without peripheral artery disease (PAD; group T2DM) and 15 with ABI