Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature

Organ shortage has driven many transplant programs to extend their criteria to accept donors. The goal of the present work is to further characterize the most important extended donor criteria (EDC) in liver transplantation and to identify factors that impact outcomes for this type of grafts through...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2007-09, Vol.22 (suppl-8), p.viii29-viii36
Main Authors: Nickkholgh, Arash, Weitz, Jürgen, Encke, Jens, Sauer, Peter, Mehrabi, Arianeb, Büchler, Markus W., Schmidt, Jan, Schemmer, Peter
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
donor age
Emergency and intensive care: renal failure. Dialysis management
extended donor criteria
Graft Survival
hepatitis
Humans
Intensive care medicine
Ischemia
ischemia time
liver transplantation
Liver Transplantation - methods
Liver, biliary tract, pancreas, portal circulation, spleen
Living Donors
malignancy
Medical sciences
Middle Aged
patient survival
Registries
Regression Analysis
Risk Factors
steatosis
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Surgery of the urinary system
Tissue and Organ Procurement - methods
Treatment Outcome
Warm Ischemia
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Summary:Organ shortage has driven many transplant programs to extend their criteria to accept donors. The goal of the present work is to further characterize the most important extended donor criteria (EDC) in liver transplantation and to identify factors that impact outcomes for this type of grafts through a comprehensive review of the most recent findings and current opinions. Age, steatosis, positive viral hepatitis serology, intensive care unit stay, and history of malignancy in donor have been the matter of substantial debate in recent years and are therefore discussed in further detail here. Cold and warm ischemic times have also been discussed separately as they have been identified as important independent risk factors for mortality. The use of grafts with EDC provides an immediate expansion of the donor pool. However, in order to optimize effective utilization of EDC, attempts should be made to carefully match the most appropriate graft-recipient pair.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfm654