Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity

Objective: The objective was to provide an overall assessment of genetic linkage data of BMI and BMI‐defined obesity using a nonparametric genome scan meta‐analysis. Research Methods and Procedures: We identified 37 published studies containing data on over 31,000 individuals from more than >10,0...

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Published in:Obesity (Silver Spring, Md.) Md.), 2007-09, Vol.15 (9), p.2263-2275
Main Authors: Saunders, Catherine L., Chiodini, Benedetta D., Sham, Pak, Lewis, Cathryn M., Abkevich, Victor, Adeyemo, Adebowale A., Andrade, Mariza, Arya, Rector, Berenson, Gerald S., Blangero, John, Boehnke, Michael, Borecki, Ingrid B., Chagnon, Yvon C., Chen, Wei, Comuzzie, Anthony G., Deng, Hong‐Wen, Duggirala, Ravindranath, Feitosa, Mary F., Froguel, Philippe, Hanson, Robert L., Hebebrand, Johannes, Huezo‐Dias, Patricia, Kissebah, Ahmed H., Li, Weidong, Luke, Amy, Martin, Lisa J., Nash, Matthew, Öhman, Miina, Palmer, Lyle J., Peltonen, Leena, Perola, Markus, Price, R. Arlen, Redline, Susan, Srinivasan, Sathanur R., Stern, Michael P., Stone, Steven, Stringham, Heather, Turner, Stephen, Wijmenga, Cisca, Collier, David A.
Format: Article
Language:English
Subjects:
Adiposity
Body Mass Index
Child & adolescent psychiatry
Diabetes
Diabetes Mellitus - genetics
Epidemiology
Genetic Linkage
Genetics
Genome, Human
Genomes
Health care
Hospitals
Humans
Hypertension
Hypertension - genetics
Medical research
Meta-analysis
Neurosciences
Obesity
Obesity - genetics
Pediatrics
Preventive medicine
Public health
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Summary:Objective: The objective was to provide an overall assessment of genetic linkage data of BMI and BMI‐defined obesity using a nonparametric genome scan meta‐analysis. Research Methods and Procedures: We identified 37 published studies containing data on over 31,000 individuals from more than >10,000 families and obtained genome‐wide logarithm of the odds (LOD) scores, non‐parametric linkage (NPL) scores, or maximum likelihood scores (MLS). BMI was analyzed in a pooled set of all studies, as a subgroup of 10 studies that used BMI‐defined obesity, and for subgroups ascertained through type 2 diabetes, hypertension, or subjects of European ancestry. Results: Bins at chromosome 13q13.2‐ q33.1, 12q23‐q24.3 achieved suggestive evidence of linkage to BMI in the pooled analysis and samples ascertained for hypertension. Nominal evidence of linkage to these regions and suggestive evidence for 11q13.3‐22.3 were also observed for BMI‐defined obesity. The FTO obesity gene locus at 16q12.2 also showed nominal evidence for linkage. However, overall distribution of summed rank p values
ISSN:1930-7381
1930-739X
DOI:10.1038/oby.2007.269