Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat

Asian ginseng ( Panax ginseng) and its close relative North American ginseng ( Panax quinquefolius) are perennial aromatic herbs that are widely used in Oriental medicine and have been acclaimed to have various health benefits including diabetes treatment. In this study, we compared the effects of a...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2007-10, Vol.14 (10), p.681-689
Main Authors: Banz, William J., Iqbal, M.J., Bollaert, Michael, Chickris, Nicole, James, Bryce, Higginbotham, D. Allan, Peterson, Richard, Murphy, Laura
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Blood Glucose - drug effects
Care and treatment
Chemical properties
Cholesterol - blood
Diabetes
Diabetes Mellitus - genetics
Diabetes Mellitus - prevention & control
Diet
DNA Primers
Dosage and administration
Gene expression
Gene Expression Regulation
Genetic aspects
Ginseng
Health aspects
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Insulin resistance
Male
Obesity
Panax
Peroxisome proliferator-activated receptor (PPAR)
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Polymerase Chain Reaction
PPAR gamma - drug effects
PPAR gamma - genetics
Rats
Rats, Zucker
Rosiglitazone maleate
Thiazolidinediones - administration & dosage
Thiazolidinediones - pharmacology
Thiazolidinediones - therapeutic use
Triglycerides - blood
Zucker Diabetic Fatty (ZDF) rat
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Summary:Asian ginseng ( Panax ginseng) and its close relative North American ginseng ( Panax quinquefolius) are perennial aromatic herbs that are widely used in Oriental medicine and have been acclaimed to have various health benefits including diabetes treatment. In this study, we compared the effects of a diet containing rosiglitazone to a diet containing ginseng ( Panax quinquefolius) in male Zucker diabetic fatty (ZDF) rats. Animals were assigned to one of three diets: control, rosiglitazone (0.1 g/1 kg diet), or ginseng (10 g/1 kg diet). During the 11-week study, body weight, food intake, organ weight, blood glucose, plasma cholesterol, and plasma triglyceride levels were evaluated. Animals treated with rosiglitazone or ginseng exhibited increased body weight ( p
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2007.06.003