Cytogenetic biclonality in a child with hypocellular primary myelodysplastic syndrome

Abstract A 13-year-old boy with hypocellular primary myelodysplastic syndrome, classified as refractory cytopenia, underwent umbilical cord blood transplantation. Cytogenetic analysis revealed two rare biclonal chromosomal aberrations, del(17)(p12) and del(11)(q23). Cytogenetic analysis was a valuab...

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Published in:Cancer genetics and cytogenetics 2007-10, Vol.178 (1), p.70-72
Main Authors: Rodrigues, Eliane Ferreira, de Souza, Daiane Corrêa, Camargo, Adriana, de Cássia Tavares, Rita, Bouzas, Luiz Fernando, Ornellas, Maria Helena, de Souza Fernandez, Teresa
Format: Article
Language:English
Subjects:
Adolescent
Chromosome Aberrations
Chromosome Banding
Chromosome Deletion
Cytogenetic Analysis
Cytogenetics
Fetal Blood - metabolism
Gene Deletion
Hematology, Oncology and Palliative Medicine
Humans
In Situ Hybridization, Fluorescence
Male
Medical Education
Myelodysplastic Syndromes - genetics
Stem Cell Transplantation
Transplantation
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Summary:Abstract A 13-year-old boy with hypocellular primary myelodysplastic syndrome, classified as refractory cytopenia, underwent umbilical cord blood transplantation. Cytogenetic analysis revealed two rare biclonal chromosomal aberrations, del(17)(p12) and del(11)(q23). Cytogenetic analysis was a valuable tool in diagnosis, in clinical decision-making, and in treatment and follow-up. To our knowledge, this is the first reported case of cytogenetic biclonality involving chromosomes 17 and 11.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2007.05.025