Solid-phase based synthesis of jasplakinolide analogs by intramolecular azide-alkyne cycloadditions

The synthesis of a focused library of jasplakinolide analogs with a 1,2,3-triazole in place of an E-configured double bond is described, featuring the Cu(I) catalyzed azide-alkyne cycloaddition reaction as an efficient macrocyclization tool.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2007-01 (38), p.3942-3944
Main Authors: Hu, Tai-Shan, Tannert, René, Arndt, Hans-Dieter, Waldmann, Herbert
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Azides - chemistry
Depsipeptides - chemical synthesis
Triazoles - chemical synthesis
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Description
Summary:The synthesis of a focused library of jasplakinolide analogs with a 1,2,3-triazole in place of an E-configured double bond is described, featuring the Cu(I) catalyzed azide-alkyne cycloaddition reaction as an efficient macrocyclization tool.
ISSN:1359-7345
1364-548X
DOI:10.1039/b710650e