Prognostic Value of Myocardial Perfusion Single-Photon Emission Computed Tomography for the Prediction of Future Cardiac Events in a Japanese Population: A Middle-Term Follow-up Study

Background The prognostic value of rest 201Tl/stress 99mTc-tetrofosmin myocardial perfusion single-photon emission computed tomography (SPECT) for the prediction of future hard cardiac events, including acute myocardial infarction (AMI), unstable angina (UAP) and cardiac death, and the implications...

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Bibliographic Details
Published in:Circulation Journal 2007, Vol.71(10), pp.1580-1585
Main Authors: Matsumoto, Naoya, Sato, Yuichi, Suzuki, Yasuyuki, Kunimasa, Taeko, Yoda, Shunichi, Iida, Jun, Nakano, Yoshimochi, Yoshimura, Akihiro, Miki, Takaaki, Kato, Masahiko, Matsuo, Shinro, Saito, Satoshi, Hirayama, Atsushi
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Coronary Syndrome - diagnostic imaging
Aged
Angina, Unstable - diagnostic imaging
Cardiac death
Coronary artery disease
Death, Sudden, Cardiac
Female
Follow-Up Studies
Heart - diagnostic imaging
Humans
Japan
Kaplan-Meier Estimate
Male
Middle Aged
Myocardial Infarction - diagnostic imaging
Predictive Value of Tests
Prognosis
Regression Analysis
Single-photon emission computed tomography
Tomography, Emission-Computed, Single-Photon - methods
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Summary:Background The prognostic value of rest 201Tl/stress 99mTc-tetrofosmin myocardial perfusion single-photon emission computed tomography (SPECT) for the prediction of future hard cardiac events, including acute myocardial infarction (AMI), unstable angina (UAP) and cardiac death, and the implications for risk stratification has not yet been defined in a Japanese population. Methods and Results The 1,988 patients who underwent rest 201Tl/stress 99mTc-tetrofosmin SPECT were identified and followed up for the occurrence of AMI, UAP and cardiac death. The mean follow-up interval was 26.9±15.8 months. The 142 patients were revascularized within 60 days after SPECT and they were censored from the prognostic analysis. Summed stress score (SSS), summed rest score and summed difference score (SDS) were calculated using a 5-point scoring (Normal: 0, No uptake: 4) and a 20-segment model; 22 cases of myocardial infarction, 31 of UAP and 22 cardiac deaths occurred (1.2%, 1.7% and 1.2%, respectively). Multivariate Cox regression analysis showed that hypertension (Wald 6.37, p
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.71.1580