Quality of life in chronic lymphocytic leukemia: an international survey of 1482 patients

Summary Although a diagnosis of chronic lymphocytic leukemia (CLL) can have a profound effect on the quality of life (QOL), few studies have objectively measured the QOL of CLL patients or compared it to the general population. We conducted an international, web‐based survey of patients with CLL usi...

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Bibliographic Details
Published in:British journal of haematology 2007-10, Vol.139 (2), p.255-264
Main Authors: Shanafelt, Tait D., Bowen, Deborah, Venkat, Chaya, Slager, Susan L., Zent, Clive S., Kay, Neil E., Reinalda, Megan, Sloan, Jeff A., Call, Timothy G.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Chi-Square Distribution
chronic lymphocytic leukemia
Comorbidity
Cost of Illness
co‐morbid health problems
Disease Progression
emotional distress
fatigue
Fatigue - psychology
Female
Hematologic and hematopoietic diseases
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - psychology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Miscellaneous
Multivariate Analysis
Neoplasms - psychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Quality of Life
Sickness Impact Profile
Statistics, Nonparametric
Stress, Psychological
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Summary:Summary Although a diagnosis of chronic lymphocytic leukemia (CLL) can have a profound effect on the quality of life (QOL), few studies have objectively measured the QOL of CLL patients or compared it to the general population. We conducted an international, web‐based survey of patients with CLL using standardized instruments with published population norms to evaluate fatigue and QOL. Co‐morbid health conditions were assessed using the Charlson Co‐Morbidity Index. Between June and October 2006, 1482 patients with CLL responded to the survey. The physical, social/family, functional, and overall QOL scores of CLL patients were similar to or better than published population norms. In contrast, the emotional well‐being scores of CLL patients were dramatically lower than that of both the general population (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2007.06791.x