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Lupus enteritis: clinical characteristics, risk factor for relapse and association with anti-endothelial cell antibody
The study was undertaken to evaluate clinical and laboratory characteristics of patients with lupus enteritis and to investigate its association with anti-endothelial cell antibodies (AECAs). Systemic lupus erythematosus (SLE) patients who were admitted to Kangnam St. Mary's Hospital with compl...
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Published in: | Lupus 2007-01, Vol.16 (10), p.803-809 |
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creator | Kwok, S.-K. Seo, S.-H. Ju, J.H. Park, K.-S. Yoon, C.-H. Kim, W.-U. Min, J.-K. Park, S.-H. Cho, C.-S. Kim, H.-Y. |
description | The study was undertaken to evaluate clinical and laboratory characteristics of patients with lupus enteritis and to investigate its association with anti-endothelial cell antibodies (AECAs). Systemic lupus erythematosus (SLE) patients who were admitted to Kangnam St. Mary's Hospital with complaints of acute abdominal pain from January 1990 to July 2006 were reviewed retrospectively. The clinical features, laboratory data and prognosis of these patients were analyzed. Among the 706 SLE patients admitted during the study period, 87 were found to admit for acute abdominal pain. Among them, 41 patients were identified with lupus enteritis. The SLE disease activity index score at admission and the mean prednisolone dose administered during the last three months prior to admission were significantly higher in patients with lupus enteritis than those with other causes (P < 0.001, P = 0.036). Serum anti-endothelial cell antibody (AECA-IgG) titer was also significantly higher in patients with lupus enteritis than those with other manifestations or healthy controls (P = 0.040, P < 0.001). Four out of 13 recurrent patients had pre-existing anti-phospholipid syndrome (APS), whereas only one out of 28 non-recurrent patients had pre-existing APS (P = 0.028). Most of the patients with lupus enteritis showed good response to high-dose intravenous steroids and there was no death directly associated with lupus enteritis. Lupus (2007) 16, 803—809. |
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Systemic lupus erythematosus (SLE) patients who were admitted to Kangnam St. Mary's Hospital with complaints of acute abdominal pain from January 1990 to July 2006 were reviewed retrospectively. The clinical features, laboratory data and prognosis of these patients were analyzed. Among the 706 SLE patients admitted during the study period, 87 were found to admit for acute abdominal pain. Among them, 41 patients were identified with lupus enteritis. The SLE disease activity index score at admission and the mean prednisolone dose administered during the last three months prior to admission were significantly higher in patients with lupus enteritis than those with other causes (P < 0.001, P = 0.036). Serum anti-endothelial cell antibody (AECA-IgG) titer was also significantly higher in patients with lupus enteritis than those with other manifestations or healthy controls (P = 0.040, P < 0.001). Four out of 13 recurrent patients had pre-existing anti-phospholipid syndrome (APS), whereas only one out of 28 non-recurrent patients had pre-existing APS (P = 0.028). Most of the patients with lupus enteritis showed good response to high-dose intravenous steroids and there was no death directly associated with lupus enteritis. Lupus (2007) 16, 803—809.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203307082383</identifier><identifier>PMID: 17895303</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Abdomen ; Abdominal Pain - etiology ; Adult ; Antibodies ; Antiphospholipid Syndrome ; Autoantibodies - analysis ; Case-Control Studies ; Drug dosages ; Enteritis - drug therapy ; Enteritis - etiology ; Enteritis - immunology ; Female ; Hospitals ; Humans ; Internal medicine ; Ischemia ; Laboratories ; Lupus ; Lupus Erythematosus, Systemic - pathology ; Male ; Medical records ; Medicine ; Pain ; Pancreatitis ; Prednisolone - administration & dosage ; Prednisolone - therapeutic use ; Recurrence ; Retrospective Studies ; Rheumatology ; Risk Factors ; Severity of Illness Index ; Steroids ; Steroids - administration & dosage ; Steroids - therapeutic use ; Urogenital system</subject><ispartof>Lupus, 2007-01, Vol.16 (10), p.803-809</ispartof><rights>SAGE Publications © Oct 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-a46e482a8a64cdc530406405c95dfb78865bd762deffba7e400779f5be86f6fc3</citedby><cites>FETCH-LOGICAL-c393t-a46e482a8a64cdc530406405c95dfb78865bd762deffba7e400779f5be86f6fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17895303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwok, S.-K.</creatorcontrib><creatorcontrib>Seo, S.-H.</creatorcontrib><creatorcontrib>Ju, J.H.</creatorcontrib><creatorcontrib>Park, K.-S.</creatorcontrib><creatorcontrib>Yoon, C.-H.</creatorcontrib><creatorcontrib>Kim, W.-U.</creatorcontrib><creatorcontrib>Min, J.-K.</creatorcontrib><creatorcontrib>Park, S.-H.</creatorcontrib><creatorcontrib>Cho, C.-S.</creatorcontrib><creatorcontrib>Kim, H.-Y.</creatorcontrib><title>Lupus enteritis: clinical characteristics, risk factor for relapse and association with anti-endothelial cell antibody</title><title>Lupus</title><addtitle>Lupus</addtitle><description>The study was undertaken to evaluate clinical and laboratory characteristics of patients with lupus enteritis and to investigate its association with anti-endothelial cell antibodies (AECAs). Systemic lupus erythematosus (SLE) patients who were admitted to Kangnam St. Mary's Hospital with complaints of acute abdominal pain from January 1990 to July 2006 were reviewed retrospectively. The clinical features, laboratory data and prognosis of these patients were analyzed. Among the 706 SLE patients admitted during the study period, 87 were found to admit for acute abdominal pain. Among them, 41 patients were identified with lupus enteritis. The SLE disease activity index score at admission and the mean prednisolone dose administered during the last three months prior to admission were significantly higher in patients with lupus enteritis than those with other causes (P < 0.001, P = 0.036). Serum anti-endothelial cell antibody (AECA-IgG) titer was also significantly higher in patients with lupus enteritis than those with other manifestations or healthy controls (P = 0.040, P < 0.001). Four out of 13 recurrent patients had pre-existing anti-phospholipid syndrome (APS), whereas only one out of 28 non-recurrent patients had pre-existing APS (P = 0.028). Most of the patients with lupus enteritis showed good response to high-dose intravenous steroids and there was no death directly associated with lupus enteritis. Lupus (2007) 16, 803—809.</description><subject>Abdomen</subject><subject>Abdominal Pain - etiology</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Antiphospholipid Syndrome</subject><subject>Autoantibodies - analysis</subject><subject>Case-Control Studies</subject><subject>Drug dosages</subject><subject>Enteritis - drug therapy</subject><subject>Enteritis - etiology</subject><subject>Enteritis - immunology</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - pathology</subject><subject>Male</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Pain</subject><subject>Pancreatitis</subject><subject>Prednisolone - administration & dosage</subject><subject>Prednisolone - therapeutic use</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Steroids</subject><subject>Steroids - administration & dosage</subject><subject>Steroids - therapeutic use</subject><subject>Urogenital system</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFUU2LFDEQDaK4s6N3TxI8eNrWykcnaW_L4hcMeNFzk05XnKw9nTFJK_vvTTsDCwviIVR49erVxyPkBYM3jGn9FjrFOAgBGgwXRjwiGya1birOH5PNmm7W_AW5zPkWAATr1FNywbTpWgFiQ37tluOSKc4FUyghv6NuCnNwdqJub5N1K55LcPmK1s8P6isUE_X1JZzsMSO180htztEFW0Kc6e9Q9hUsocF5jGWPU1jlcJr-okMc756RJ95OGZ-f45Z8-_D-682nZvfl4-eb613jRCdKY6VCabg1Vkk3ujqyBCWhdV07-kEbo9ph1IqP6P1gNUoArTvfDmiUV96JLXl90j2m-HPBXPpDyOskdsa45F4ZwdqOy_8SOcjWQD3alrx6QLyNS5rrEj3nXAne1XtvCZxILsWcE_r-mMLBprueQb861z90rpa8POsuwwHH-4KzVZXQnAjZfsf7pv8U_ANILaGs</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Kwok, S.-K.</creator><creator>Seo, S.-H.</creator><creator>Ju, J.H.</creator><creator>Park, K.-S.</creator><creator>Yoon, C.-H.</creator><creator>Kim, W.-U.</creator><creator>Min, J.-K.</creator><creator>Park, S.-H.</creator><creator>Cho, C.-S.</creator><creator>Kim, H.-Y.</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Lupus enteritis: clinical characteristics, risk factor for relapse and association with anti-endothelial cell antibody</title><author>Kwok, S.-K. ; Seo, S.-H. ; Ju, J.H. ; Park, K.-S. ; Yoon, C.-H. ; Kim, W.-U. ; Min, J.-K. ; Park, S.-H. ; Cho, C.-S. ; Kim, H.-Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-a46e482a8a64cdc530406405c95dfb78865bd762deffba7e400779f5be86f6fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Abdomen</topic><topic>Abdominal Pain - etiology</topic><topic>Adult</topic><topic>Antibodies</topic><topic>Antiphospholipid Syndrome</topic><topic>Autoantibodies - analysis</topic><topic>Case-Control Studies</topic><topic>Drug dosages</topic><topic>Enteritis - drug therapy</topic><topic>Enteritis - etiology</topic><topic>Enteritis - immunology</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - pathology</topic><topic>Male</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Pain</topic><topic>Pancreatitis</topic><topic>Prednisolone - administration & dosage</topic><topic>Prednisolone - therapeutic use</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Steroids</topic><topic>Steroids - administration & dosage</topic><topic>Steroids - therapeutic use</topic><topic>Urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwok, S.-K.</creatorcontrib><creatorcontrib>Seo, S.-H.</creatorcontrib><creatorcontrib>Ju, J.H.</creatorcontrib><creatorcontrib>Park, K.-S.</creatorcontrib><creatorcontrib>Yoon, C.-H.</creatorcontrib><creatorcontrib>Kim, W.-U.</creatorcontrib><creatorcontrib>Min, J.-K.</creatorcontrib><creatorcontrib>Park, S.-H.</creatorcontrib><creatorcontrib>Cho, C.-S.</creatorcontrib><creatorcontrib>Kim, H.-Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwok, S.-K.</au><au>Seo, S.-H.</au><au>Ju, J.H.</au><au>Park, K.-S.</au><au>Yoon, C.-H.</au><au>Kim, W.-U.</au><au>Min, J.-K.</au><au>Park, S.-H.</au><au>Cho, C.-S.</au><au>Kim, H.-Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lupus enteritis: clinical characteristics, risk factor for relapse and association with anti-endothelial cell antibody</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>16</volume><issue>10</issue><spage>803</spage><epage>809</epage><pages>803-809</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>The study was undertaken to evaluate clinical and laboratory characteristics of patients with lupus enteritis and to investigate its association with anti-endothelial cell antibodies (AECAs). Systemic lupus erythematosus (SLE) patients who were admitted to Kangnam St. Mary's Hospital with complaints of acute abdominal pain from January 1990 to July 2006 were reviewed retrospectively. The clinical features, laboratory data and prognosis of these patients were analyzed. Among the 706 SLE patients admitted during the study period, 87 were found to admit for acute abdominal pain. Among them, 41 patients were identified with lupus enteritis. The SLE disease activity index score at admission and the mean prednisolone dose administered during the last three months prior to admission were significantly higher in patients with lupus enteritis than those with other causes (P < 0.001, P = 0.036). Serum anti-endothelial cell antibody (AECA-IgG) titer was also significantly higher in patients with lupus enteritis than those with other manifestations or healthy controls (P = 0.040, P < 0.001). Four out of 13 recurrent patients had pre-existing anti-phospholipid syndrome (APS), whereas only one out of 28 non-recurrent patients had pre-existing APS (P = 0.028). Most of the patients with lupus enteritis showed good response to high-dose intravenous steroids and there was no death directly associated with lupus enteritis. Lupus (2007) 16, 803—809.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>17895303</pmid><doi>10.1177/0961203307082383</doi><tpages>7</tpages></addata></record> |
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subjects | Abdomen Abdominal Pain - etiology Adult Antibodies Antiphospholipid Syndrome Autoantibodies - analysis Case-Control Studies Drug dosages Enteritis - drug therapy Enteritis - etiology Enteritis - immunology Female Hospitals Humans Internal medicine Ischemia Laboratories Lupus Lupus Erythematosus, Systemic - pathology Male Medical records Medicine Pain Pancreatitis Prednisolone - administration & dosage Prednisolone - therapeutic use Recurrence Retrospective Studies Rheumatology Risk Factors Severity of Illness Index Steroids Steroids - administration & dosage Steroids - therapeutic use Urogenital system |
title | Lupus enteritis: clinical characteristics, risk factor for relapse and association with anti-endothelial cell antibody |
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