Oocyte Maturation in Assisted Reproductive Techniques

:  Human oocyte maturation is a long process during which nuclear maturation occurs resulting in germinal vesicle breakdown (transition from prophase I to metaphase II) and extrusion of the first polar body. During oocyte maturation, in parallel with nuclear maturation, a number of events take place...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2006-12, Vol.1092 (1), p.235-246
Main Authors: LOUTRADIS, DIMITRIS, KIAPEKOU, ERASMIA, ZAPANTI, EVANGELIA, ANTSAKLIS, ARISTIDIS
Format: Article
Language:English
Subjects:
cryopreservation
Female
fertilization
folliculogenesis
Humans
in vitro maturation
Oocytes - physiology
Reproductive Techniques, Assisted
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Summary::  Human oocyte maturation is a long process during which nuclear maturation occurs resulting in germinal vesicle breakdown (transition from prophase I to metaphase II) and extrusion of the first polar body. During oocyte maturation, in parallel with nuclear maturation, a number of events take place in the oocyte cytoplasm that assist fertilization and early embryonic development. So far several attempts have been made to mature human oocytes in vitro. The main patient group to which in vitro maturation (IVM) has been applied is polycystic ovarian syndrome. In a concise review we present the techniques used for the IVM of oocytes and the role of hormones and growth factors in IVM and subsequent fertilization and early embryonic development.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1365.020