Troponin I release at rest and after exercise in patients with hypertrophic cardiomyopathy and the effect of betablockade

In patients with hypertrophic cardiomyopathy ischemia may occur due to massive heart weight, myocyte disarray or small vessel disease. We detected elevated troponin levels in some of these patients and hypothesized that troponin release would rise after exercise and diminish after betablockade. In 5...

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Bibliographic Details
Published in:Archivos de cardiología de México 2006-10, Vol.76 (4), p.415-418
Main Authors: Pop, Gheorghe A M, Cramer, Etienne, Timmermans, Janneke, Bos, Hans, Verheugt, Freek W A
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - administration & dosage
Adrenergic beta-Antagonists - pharmacology
Adrenergic beta-Antagonists - therapeutic use
Adult
Atenolol - administration & dosage
Atenolol - pharmacology
Atenolol - therapeutic use
Cardiomyopathy, Hypertrophic - blood
Cardiomyopathy, Hypertrophic - drug therapy
Cardiomyopathy, Hypertrophic - physiopathology
Exercise
Exercise Test
Female
Humans
Male
Metoprolol - administration & dosage
Metoprolol - pharmacology
Metoprolol - therapeutic use
Middle Aged
Time Factors
Troponin I - blood
Troponin I - drug effects
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Summary:In patients with hypertrophic cardiomyopathy ischemia may occur due to massive heart weight, myocyte disarray or small vessel disease. We detected elevated troponin levels in some of these patients and hypothesized that troponin release would rise after exercise and diminish after betablockade. In 5 of 7 young patients (6 males) with hypertrophic cardiomyopathy and no overt coronary artery disease we found elevated troponin levels after physical exercise; the peak was between 6 and 9 hours and levels returned to pre-exercise values within 24 hours. Troponin release was consistently diminished after use of a betablocker. Increased troponin release may be present in patients with hypertrophic cardiomyopathy and is temporarily enhanced by exercise and diminishes with betablockade.
ISSN:1405-9940