A new consecutive three-component oxazole synthesis by an amidation-coupling-cycloisomerization (ACCI) sequence

A novel consecutive three-component synthesis of 1-(hetero)-aryl-2-(2-(hetero)aryl-oxazol-5-yl) ethanones starting from propargyl amine and acid chlorides, both for amidation and cross-coupling, is based upon an amidation-coupling-cycloisomerization (ACCI) sequence.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2006-01 (46), p.4817-4819
Main Authors: Merkul, Eugen, Müller, Thomas J J
Format: Article
Language:English
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Summary:A novel consecutive three-component synthesis of 1-(hetero)-aryl-2-(2-(hetero)aryl-oxazol-5-yl) ethanones starting from propargyl amine and acid chlorides, both for amidation and cross-coupling, is based upon an amidation-coupling-cycloisomerization (ACCI) sequence.
ISSN:1359-7345
1364-548X
DOI:10.1039/b610839c