Treatment of detrusor sphincter dyssynergia with baclofen and doxazosin

Detrusor sphincter dyssynergia (DSD) is an involuntary contraction of the external urethral sphincter during detrusor contraction. A high proportion of patients needing repeat surgery and long term failure have both been described in the literature. In the present study, we evaluated clinical charac...

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Bibliographic Details
Published in:International urology and nephrology 2006-01, Vol.38 (3-4), p.537-541
Main Authors: Kilicarslan, H, Ayan, S, Vuruskan, H, Gokce, G, Gultekin, E Y
Format: Article
Language:English
Subjects:
Adolescent
Adrenergic alpha-Antagonists - therapeutic use
Adult
Aged
Baclofen - therapeutic use
Doxazosin - therapeutic use
Female
Humans
Middle Aged
Muscle Contraction
Muscle Relaxants, Central - therapeutic use
Urethral Diseases - drug therapy
Urethral Diseases - physiopathology
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Summary:Detrusor sphincter dyssynergia (DSD) is an involuntary contraction of the external urethral sphincter during detrusor contraction. A high proportion of patients needing repeat surgery and long term failure have both been described in the literature. In the present study, we evaluated clinical characteristics, underlying disorders and outcomes of conservative medical treatment in 21 female patients. Two patients were newly diagnosed multiple sclerosis. Urodynamic studies were performed in all symptomatic patients, and consisted of measurement of post-micturition residuals, urethral pressure profilometry and EMG cystometry according to the criteria of the International Continence Society. All patients were treated with baclofen 15 mg/day and doxazosin 4 mg/day. Seven patients received tolterodine 4 mg/day in addition to baclofen and doxazocin because they had detrusor hyperreflexia (DH). In conclusion, treatment with either combined baclofen and doxazosin or anticholinergic agent tolterodine appeared to be effective. In addition, it should be kept in mind that DSD could be the first sign to any neurologic diseases.
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-006-0071-9