Effects of estradiol on synthesis of corticosteroids, protein kinase A and C activity in the adrenal cortex of intact and orchiectomized rats

Estradiol treatment produced significant increase of total 11-hydroxycorticosteroids level in the blood of intact and castrated rats. Activity of protein kinase A increased in the cytosol and membrane fraction of adrenocorticocytes of intact and orchiectomized rats after estradiol influence. Activit...

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Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2006, Vol.52 (6), p.30-34
Main Authors: Tron'ko, M D, Kovzun, O I, Hrinchenko, Ie M, Mykosha, O S
Format: Article
Language:Ukrainian
Subjects:
11-Hydroxycorticosteroids - biosynthesis
11-Hydroxycorticosteroids - blood
Adrenal Cortex - cytology
Adrenal Cortex - drug effects
Adrenal Cortex - enzymology
Adrenal Cortex - metabolism
Animals
Cyclic AMP-Dependent Protein Kinases - metabolism
Cytosol - drug effects
Cytosol - enzymology
Cytosol - metabolism
Estradiol - analogs & derivatives
Estradiol - pharmacology
Male
Microsomes - drug effects
Microsomes - enzymology
Microsomes - metabolism
Orchiectomy
Protein Kinase C - metabolism
Rats
Rats, Wistar
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Summary:Estradiol treatment produced significant increase of total 11-hydroxycorticosteroids level in the blood of intact and castrated rats. Activity of protein kinase A increased in the cytosol and membrane fraction of adrenocorticocytes of intact and orchiectomized rats after estradiol influence. Activity of protein kinase C significantly raised in the cytosol and membrane fraction of adrenocortical cells in all investigated groups. Our results suggest that cAMP-dependent protein kinase A and protein kinase C mediate estradiol effects in adrenal cortex.
ISSN:2522-9028